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M5273

Monensin sodium salt

90-95% (TLC), Sodium ionophore

Synonym(s):

Monensin A sodium salt

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About This Item

Empirical Formula (Hill Notation):
C36H61NaO11
CAS Number:
22373-78-0
Molecular Weight:
692.85
NACRES:
NA.77
PubChem Substance ID:
24896992
UNSPSC Code:
12352200
EC Number:
244-941-7
MDL number:
MFCD00077826
Beilstein/REAXYS Number:
4122200
Assay:
90-95% (TLC)
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Product Name

Monensin sodium salt, 90-95% (TLC)

Quality Segment

200

assay

90-95% (TLC)

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, fungi, parasites, viruses

mode of action

cell membrane | interferes

storage temp.

2-8°C

SMILES string

[H][C@]1([C@@]2(CC)O[C@]([C@@]3(C)OC4(C[C@H](O)[C@@H](C)[C@@]([H])([C@@H](C)[C@@H](OC)[C@@H](C([O-])=O)C)O4)CC3)([H])CC2)[C@@H](C)C[C@]([H])([C@@]5([H])O[C@@](O)(CO)[C@H](C)C[C@@H]5C)O1.[Na+]

InChI

1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35?,36-;/m0./s1

InChI key

XOIQMTLWECTKJL-BEMBKCOJSA-M

General description

Chemical structure: polyether
Monensin is a polyether ionophoric antibiotic, which is produced by Streptomyces cinnamonensis. It is used to treat bacterial, fungal and parasitic infections. Monensin prevents the growth of colon cancer cells. It facilitates the transport of sodium and potassium ions between intracellular and extracellular spaces. Monensin prevents coccidiosis in poultry production.

Application

Monensin sodium salt has been used:
  • for the intracellular staining of cytokines
  • to study its effects on the regulation of nuclear factor-κ B (NF-κB ) activation
  • as a positive control to study its effects on in vitro rumen fermentation

Biochem/physiol Actions

Na+ ionophore; blocks glycoprotein secretion; may induce catecholamine secretion from chromaffin cells. Useful in potentiometric and spectroscopic studies of alkali metal ion complexes.

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - STOT RE 2

target_organs

Heart,muscle

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Deleterious substance

pdsc

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

M5273-5G:4.548173202952E12 + M5273-1G:4.548173202938E12 + M5273-500MG:4.548173202945E12

jan

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