P7791

Prazosin hydrochloride

Name: Prazosin hydrochloride
Brand: SIGMA

≥99.0% (HPLC), powder, α1-adrenoceptor antagonist

Synonym(s):

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride, Furazosin hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₁N₅O₄ · HCl

CAS Number:

19237-84-4

Molecular Weight:

419.86

NACRES:

NA.77

PubChem Substance ID:

24277793

UNSPSC Code:

12352200

EC Number:

242-903-4

MDL number:

MFCD00058177

Beilstein/REAXYS Number:

4303561

Assay:

≥99.0% (HPLC)

Form:

powder

Quality level:

100

Key Documents

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Product Name

Prazosin hydrochloride, ≥99.0% (HPLC)

InChI key

WFXFYZULCQKPIP-UHFFFAOYSA-N

InChI

1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H

SMILES string

Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4

assay

≥99.0% (HPLC)

form

powder

solubility

H₂O: 0.5 mg/mL, methanol: 6 mg/mL, dilute aqueous acid: insoluble

Quality Level

100

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

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Bioactive Small Molecules

Application

Prazosin hydrochloride has been used:

to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in mice
as an α1-adrenoceptor blocker,administered intragastrically in rats
as a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions

Biochem/physiol Actions

Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin can be used to treat chronic posttraumatic stress disorder (PTSD). It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure.

Disclaimer

Hygroscopic; light sensitive.

Features and Benefits

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the α1-Adrenoceptors, α2-Adrenoceptors and Melatonin Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Prazosin is a member of the class of α-adrenergic blockers. It is considered as a peripheral vasodilator antihypertensive agent. Prazosin is a derivative of quinazoline.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H336,H361fd,H373

pcodes

P202 - P260 - P271 - P280 - P304 + P340 + P312 - P308 + P313

Hazard Classifications

Repr. 2 - STOT RE 2 - STOT SE 3

target_organs

Central nervous system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

P7791-BULK: + P7791-250MG: + P7791-50MG: + P7791-VAR: + P7791-1G:

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Certificates of Analysis (COA)

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Find documentation for the products that you have recently purchased in the Document Library.

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Initial orthostatic hypotension and cerebral blood flow regulation: effect of α1-adrenoreceptor activity.

Nia C S Lewis et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 304(2), R147-R154 (2012-11-24)

We examined the hypothesis that α(1)-adrenergic blockade would lead to an inability to correct initial orthostatic hypotension (IOH) and cerebral hypoperfusion, leading to symptoms of presyncope. Twelve normotensive humans (aged 25 ± 1 yr; means ± SE) attempted to complete

A trial of prazosin for combat trauma PTSD with nightmares in active-duty soldiers returned from Iraq and Afghanistan.

Murray A Raskind et al.

The American journal of psychiatry, 170(9), 1003-1010 (2013-07-13)

The authors conducted a 15-week randomized controlled trial of the alpha-1 adrenoreceptor antagonist prazosin for combat trauma nightmares, sleep quality, global function, and overall symptoms in active-duty soldiers with posttraumatic stress disorder (PTSD) returned from combat deployments to Iraq and

Enhanced salt sensitivity following shRNA silencing of neuronal TRPV1 in rat spinal cord

Yu S Q and Wang D H

Acta Pharmacologica Sinica, 32(6), 845-845 (2011)

Haptoglobin reduces renal oxidative DNA and tissue damage during phenylhydrazine-induced hemolysis

Lim Y K, et al.

Kidney International, 58(3), 1033-1044 (2000)

(11)C-CUMI-101, a PET radioligand, behaves as a serotonin 1A receptor antagonist and also binds to α(1) adrenoceptors in brain.

Stal Saurav Shrestha et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(1), 141-146 (2014-01-05)

The PET radioligand (11)C-CUMI-101 was previously suggested as a putative agonist radioligand for the serotonin 1A (5-hydroxytryptamine 1A [5-HT1A]) receptor in recombinant cells expressing human 5-HT1A receptor. However, a recent study showed that CUMI-101 behaved as a potent 5-HT1A receptor

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Prazosin hydrochloride

≥99.0% (HPLC), powder, α1-adrenoceptor antagonist

Select a Size

About This Item

Key Documents

Properties

Product Name

InChI key

InChI

SMILES string

assay

form

solubility

Quality Level

Gene Information

Related Categories

Description

Application

Biochem/physiol Actions

Disclaimer

Features and Benefits

General description

Packaging

Safety Information

pictograms

signalword

hcodes

pcodes

Hazard Classifications

target_organs

Storage Class

wgk

flash_point_f

flash_point_c

ppe

Regulatory Listings

P7791-BULK: + P7791-250MG: + P7791-50MG: + P7791-VAR: + P7791-1G:

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Peer Reviewed Papers

Protocols and Articles

Articles

Related Content

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