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Merck

P9879

Procaine hydrochloride

≥97% (HPLC), powder, Na⁺ channel blocker

Synonym(s):

4-Aminobenzoic acid 2-diethylaminoethyl ester, p-Aminobenzoic acid diethylaminoethyl ester hydrochloride, Novocaine hydrochloride

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About This Item

Linear Formula:
H2NC6H4CO2CH2CH2N(C2H5)2·HCl
CAS Number:
51-05-8
Molecular Weight:
272.77
NACRES:
NA.77
PubChem Substance ID:
24278665
UNSPSC Code:
12352200
EC Number:
200-077-2
MDL number:
MFCD00013000
Beilstein/REAXYS Number:
3917802
Assay:
≥97%
Form:
powder
Quality level:
200

Key Documents

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Product Name

Procaine hydrochloride, ≥97%

InChI key

HCBIBCJNVBAKAB-UHFFFAOYSA-N

InChI

1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H

SMILES string

Cl.CCN(CC)CCOC(=O)c1ccc(N)cc1

assay

≥97%

form

powder

mp

155-156 °C (lit.)

originator

Celgene

Quality Level

200

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

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Application

Procaine hydrochloride has been used as a component of Krebs Henseleit buffer for incubating the left ventricular cardiac tissue in its resting length. It has also been used as an inducer in M9 media for induction assay.

Biochem/physiol Actions

Procaine is a Na+ channel blocker, commonly used as an anesthetic agent and is considered safer than cocaine. It is also useful as a painkiller to treat pain, associated with joints and tendons.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Celgene. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H317

Hazard Classifications

Acute Tox. 3 Oral - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

P9879-VAR: + P9879-BULK: + P9879-100G: + P9879-50G: + P9879-250G:

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Certificates of Analysis (COA)

Lot/Batch Number
0000504519
0000504519
0000455498
0000455497
0000455497

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Phillippe P Gonzalez et al.
Glia, 66(5), 999-1015 (2018-02-03)
Malignant glioma is one of the deadliest types of cancer. Understanding how the cell of origin progressively evolves toward malignancy in greater detail could provide mechanistic insights and lead to novel concepts for tumor prevention and therapy. Previously we have
Characterization of combinatorial patterns generated by multiple two-component sensors in E. coli that respond to many stimuli
Clarke EJ and Voigt CA
Biotechnology and Bioengineering, 108(3), 666-675 (2011)
Ophthalmic Anaesthesia, 5-5 (2002)
Equine Anesthesia E-Book: Monitoring and Emergency Therapy, 215-215 (2002)
Cardiac and metabolic changes in long-term high fructose-fat fed rats with severe obesity and extensive intramyocardial lipid accumulation
Axelsen LN, et al.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 298(6), R1560-R1570 (2010)
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