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WH0000675M1

Monoclonal Anti-BRCA2 antibody produced in mouse

clone 3D12, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-FACD, Anti-FAD, Anti-FAD1, Anti-FANCB, Anti-FANCD, Anti-FANCD1, Anti-breast cancer 2, early onset

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD01321778
Conjugate:
unconjugated
Clone:
3D12, monoclonal
Application:
ELISA (i), WB
Citations:
5
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biological source

mouse

Quality Segment

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3D12, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable, western blot: 1-5 μg/mL

isotype

IgG3κ

GenBank accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BRCA2(675)

General description

Breast cancer type 2 susceptibility protein (BRCA2), DNA repair associated gene is located on human chromosome 13q13.1. BRCA2 and BRCA1 colocalize in subnuclear foci in somatic cells and on the axial elements of developing synaptonemal complexes.

Immunogen

BRCA2 (NP_000050, 3319 a.a. ~ 3418 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
SPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEKQFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI

Biochem/physiol Actions

Breast cancer type 2 susceptibility protein (BRCA2), DNA repair associated protein encodes a protein that promotes homologous recombination, which is essential for normal development. Mutations causes tumor formation and cell lethality. Bi-allelic mutations of BRCA2 is associated with Fanconi anemia (FA). BRCA2 alterations can be used as a prognostic marker for pancreatic cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

WH0000675M1-100UG:

jan

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