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Merck

1.06432

tri-Sodium citrate dihydrate

crystalline, EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, USP, E 331

Synonym(s):

Sodium citrate tribasic dihydrate, Trisodium Citrate, Sodium Citrate, Dihydrate, Citric acid trisodium salt dihydrate, Trisodium citrate dihydrate

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About This Item

Linear Formula:
HOC(COONa)(CH2COONa)2 · 2H2O
CAS Number:
6132-04-3
Molecular Weight:
294.10
UNSPSC Code:
12352107
EC Index Number:
200-675-3
E Number:
E331
MDL number:
MFCD00150031
Beilstein/REAXYS Number:
6104939

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Product Name

tri-Sodium citrate dihydrate, crystalline, EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, USP, E 331

InChI

1S/C6H8O7.3Na.2H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;2*1H2/q;3*+1;;/p-3

SMILES string

O.O.[Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

InChI key

NLJMYIDDQXHKNR-UHFFFAOYSA-K

agency

BP
JP
Ph. Eur.
USP

product line

EMPROVE® ESSENTIAL

form

crystalline
solid

pH

7.5-9.0 (25 °C, 50 g/L in H2O)

pKa 

(1) 3.1, (2) 4.8, (3) 6.4

mp

150 °C (anhydrous substance)
>300 °C (lit.)

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

2-30°C

Quality Level

500

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Application

tri-Sodium citrate dihydrate is typically used as a citrate buffer system component for biomolecule downstream chromatography steps or final liquid formulation.

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
1.06432.100004022536076621
1.06432.902904022536940090
1.06432.500004022536076645

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