204903
Anti-Complement 5b-9 Rabbit pAb
liquid, Calbiochem®
Synonym(s):
Anti-Terminal Complement Complex, Anti-Membrane Attack Complex, Anti-MAC
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About This Item
NACRES:
NA.43
UNSPSC Code:
12352203
Clone:
polyclonal
Species reactivity:
human, mouse
Application:
—
Citations:
18
biological source
rabbit
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
form
liquid
contains
≤0.1% sodium azide as preservative
species reactivity
human, mouse
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles
dilution
(Frozen Sections
Immunofluorescence
Paraffin Sections (heat pre-treatment required)
Radial Immunodiffusion (use undiluted))
isotype
IgG
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
Protein A purified rabbit polyclonal antibody. Recognizes the C5b-C9 complement component complex.
Recognizes complement component complex Cb5-C9.
This Anti-Complement 5b-9 Rabbit pAb is validated for use in Frozen Sections, Immunofluorescence, Paraffin Sections, Radial Immunodiffusion for the detection of Complement 5b-9.
Immunogen
Human
purified human SC5b-9 complex
Application
Frozen Sections (see application references)
Immunofluorescence (see comments)
Paraffin Sections (see comments, heat pre-treatment required)
Radial Immunodiffusion (use undiluted)
Immunofluorescence (see comments)
Paraffin Sections (see comments, heat pre-treatment required)
Radial Immunodiffusion (use undiluted)
Packaging
Please refer to vial label for lot-specific concentration.
Physical form
In PBS, pH 7.2.
Preparation Note
Following intial thaw, aliquot and freeze (-20°C).
Other Notes
By immunodiffusion the antibody is monospecific for C5b-9 complex in purified form or present in cobra venom factor activated human serum. There is no reactivity vs. non-activated normal human serum or plasma. Also reported to work for immunofluorescence. This antibody has been shown to work for formalin-fixed paraffin sections; use of citrate buffer and a pressure cooker for 1 min is required for antigen retrieval. Antibody should be titrated for optimal results in individual systems.
Schafer, H., et al. 1986. J. Immunol.137, 1945.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Melina V Jones et al.
Journal of immunology research, 2018, 9034695-9034695 (2019-01-17)
To reduce immune-mediated damage in a rat model of neuromyelitis optica (NMO) by blocking neutrophil migration using SCH527123, a drug that inhibits CXCR2. Neuromyelitis optica is a relapsing autoimmune disease that preferentially targets the optic nerves and spinal cord leading
Jean F Regal et al.
Molecular immunology, 78, 38-47 (2016-09-03)
Preeclampsia is characterized by development of hypertension during pregnancy and reduced placental perfusion. Previous studies in a rat model of placental ischemia-induced hypertension demonstrated that inhibiting complement activation attenuated increased maternal blood pressure with C3a and C5a identified as the
Maria Martin et al.
Kidney international reports, 9(7), 2227-2239 (2024-07-31)
Atypical hemolytic uremic syndrome (aHUS) is a complement system (CS)-mediated ultrarare disease that manifests as thrombotic microangiopathy (TMA) with preferential small kidney vessels involvement. Transient CS activation is also observed in secondary TMA or in patients at risk of developing