SML0579
EVP4593
≥98% (HPLC)
Synonym(s):
4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine, N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine, QNZ
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About This Item
Empirical Formula (Hill Notation):
C22H20N4O
CAS Number:
Molecular Weight:
356.42
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 15 mg/mL, clear
storage temp.
2-8°C
SMILES string
NC1=CC(C(NCCC2=CC=C(OC3=CC=CC=C3)C=C2)=NC=N4)=C4C=C1
InChI
1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26)
InChI key
IBAKVEUZKHOWNG-UHFFFAOYSA-N
Biochem/physiol Actions
EVP4593 is a high affinity partial antagonist of NF-KB pathway activation acting by inhibiting store-operated calcium (Ca2+) entry (SOC).
EVP4593 is a high affinity partial antagonist of NF-KB pathway activation acting by inhibiting store-operated calcium (Ca2+) entry (SOC). It appears that EVP4593 targets heteromeric channels containing TRPC1 as one of the subunits in HD neurons. EVP4593 exhibits neuroprotective effects from glutamate toxicity in nanomolar concentrations.
Features and Benefits
This compound is featured on the Calcium Channels, Cytokine Receptors (Interleukin-1 Receptor/TIR Family) and Cytokine Receptors (Tumor Necrosis Receptor Family) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Other Notes
Air sensitive
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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