288144
Tricarbonyldichlororuthenium(II) dimer
Synonym(s):
CORM-2
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Linear Formula:
[Ru(CO)3Cl2]2
CAS Number:
Molecular Weight:
512.01
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12161600
MDL number:
InChI
1S/6CO.4ClH.2Ru/c6*1-2;;;;;;/h;;;;;;4*1H;;/q;;;;;;;;;;2*+2/p-4
SMILES string
[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].Cl[Ru]Cl.Cl[Ru]Cl
InChI key
JYHHJVKGDCZCCL-UHFFFAOYSA-J
reaction suitability
core: ruthenium, reagent type: catalyst
Quality Level
Application
Carbon monoxide-releasing molecule used for pharamological studies including:
Used as a CO donor for reactive oxygen species mediated bacterial killing
- Enhancement of coagulation and attenuation of vulnerability to fibrinolysis
- Investigations of P2X4 as a possible target
- Possible modification of thrombus growth or disintegration
- Enhances fibrinogen as a substrate for thrombin
- Regulation of ion transport by gasotransmitters
Used as a CO donor for reactive oxygen species mediated bacterial killing
Tricarbonyldichlororuthenium(II) dimer can be used in the deuteration reaction for labeling secondary amines. It can also be used for the synthesis of racemization catalysts by reacting with cyclopenta[l]phenanthrenyl and cyclopenta[a]acenaphthylenyl ligands.
signalword
Warning
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
One-step exchange-labelling of piperidines, piperazines and dialkylamines with deuterium oxide: catalysis by various ruthenium complexes.
Alexakis E, et al.
Tetrahedron Letters, 46(25), 4291-4293 (2005)
Po-Min Yang et al.
Vascular pharmacology, 87, 209-218 (2016-10-11)
The production of nitric oxide (NO) by endothelial NO synthase (eNOS) plays a major role in maintaining vascular homeostasis. This study elucidated the potential role of carbon monoxide (CO)-releasing molecules (CORMs) in NO production and explored the underlying mechanisms in
Cyclopenta [l] phenanthrenyl and Cyclopenta [a] acenaphthylenyl Half-Sandwich Complexes of Ruthenium as Racemization Catalysts for Secondary Alcohols.
Mavrynsky D, et al.
Organometallics, 28(2), 598-605 (2008)
Vance G Nielsen et al.
International journal of molecular sciences, 21(6) (2020-03-22)
Using thrombelastography to gain mechanistic insights, recent investigations have identified enzymes and compounds in Naja and Crotalus species' neurotoxic venoms that are anticoagulant in nature. The neurotoxic venoms of the four extant species of Dendroaspis (the Black and green mambas)
Vance G Nielsen et al.
Basic & clinical pharmacology & toxicology, 122(1), 157-164 (2017-07-12)
Several in vitro investigations have demonstrated that anticoagulant effects of fibrinogenolytic snake venom metalloproteinases have been abrogated in human plasma by modifying fibrinogen with iron (Fe) and carbon monoxide (CO) to prevent catalysis or by directly inhibiting these enzymes with CO.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service