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Merck

791725

Citric acid

anhydrous grade, ACS reagent grade, ≥99.5%, Redi-Dri, free-flowing, crystals

Synonym(s):

2-Hydroxy-propane-1,2,3-tricarboxylic acid

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About This Item

Linear Formula:
HOC(COOH)(CH2COOH)2
CAS Number:
Molecular Weight:
192.12
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
201-069-1
MDL number:
Beilstein/REAXYS Number:
782061

Product Name

Citric acid, anhydrous, free-flowing, Redi-Dri, ACS reagent, ≥99.5%

InChI key

KRKNYBCHXYNGOX-UHFFFAOYSA-N

InChI

1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

SMILES string

OC(=O)CC(O)(CC(O)=O)C(O)=O

grade

ACS reagent
anhydrous

product line

Redi-Dri

assay

≥99.5%

form

crystals

quality

free-flowing

expl. lim.

8 %, 65 °F

impurities

Substances carbonizable by hot sulfuric acid, passes test

ign. residue

≤0.02%

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

mp

153-159 °C (lit.)

anion traces

chloride (Cl-): ≤0.001%
oxalate (C2O42-): passes test (limit about 0.003%)
phosphate (PO43-): ≤0.001%
sulfate (SO42-): ≤0.002%

cation traces

Fe: ≤3 ppm
Pb: ≤2 ppm

functional group

carboxylic acid
hydroxyl

Quality Level

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Application

Citric acidhas been used as a component of citrate buffer and Fe-free sauton′s medium. It has been used in hybridization chain reaction buffer for preequilibration of coverslips for testes sections.

General description

Citric acid also called 2-hydroxy-propane-1,2,3-tricarboxylic acid, is a component of the tricarboxylic acid cycle in all organisms. Industrial production of citric acid use fungal, yeast and citrus fruit as the major source. Aspergillus niger is majorly used for citric acid production by fermentation Manganese inhibits fermentative production of citric acid Oral supplementation of citric acid promotes tricarboxylic acid cycle and oxidative phosphorylation in mitochondria, attenuating physical fatigue.

Legal Information

Redi-Dri is a trademark of Sigma-Aldrich Co. LLC
Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Biotechnological production of citric acid
Max B, et al.
Brazilian Journal of Microbiology, 41(4), 862-875 (2010)
Two promoters in the esx-3 gene cluster of Mycobacterium smegmatis respond inversely to different iron concentrations in vitro
Fang Z, et al.
BMC Research Notes, 10(1), 426-426 (2017)
Methylene blue exerts a neuroprotective effect against traumatic brain injury by promoting autophagy and inhibiting microglial activation
Zhao M, et al.
Molecular Medicine Reports, 13(1), 13-20 (2016)
Effects of citric acid and L-carnitine on physical fatigue
Sugino T, et al.
Journal of Clinical Biochemistry and Nutrition, 41(3), 224-230 (2007)
A comprehensive roadmap of murine spermatogenesis defined by single-cell RNA-seq
Green CD, et al.
Developmental Cell, 46(5), 651-667 (2018)

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