L1026

Lidocaine

Name: Lidocaine
Brand: SIGMA

Na+ channel blocker, solid

Synonym(s):

2-Diethylamino-N-(2,6-dimethylphenyl)acetamide, Lignocaine, Xylocaine

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All Photos(2)

About This Item

Empirical Formula (Hill Notation):

C₁₄H₂₂N₂O

CAS Number:

137-58-6

Molecular Weight:

234.34

NACRES:

NA.77

PubChem Substance ID:

24896272

UNSPSC Code:

12352200

EC Number:

205-302-8

MDL number:

MFCD00026733

Product Name

Lidocaine, analytical standard

InChI key

NNJVILVZKWQKPM-UHFFFAOYSA-N

InChI

1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)

SMILES string

CCN(CC)CC(=O)Nc1c(C)cccc1C

grade

analytical standard

form

solid

packaging

vial of 200 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤0.5% Total Organic Impurities (Lidocaine related compound H ≤0.10%

2,6-Dimethylaniline ≤0.01%

Any unspecified impurity ≤0.10%

Total impurities ≤0.5%)

application(s)

forensics and toxicology
pharmaceutical (small molecule)

Quality Level

200

Gene Information

human ... CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Scnn1a(25122)

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Related Categories

Analytical Chemistry

Analytical Chromatography

Bioactive Small Molecules

Chromatography Standards

Controlled Substances & Illicit Drug Standards

Application

Lidocaine has been used to examine its effects in inhibiting lymph flow and protection against envenomation. It has also been used to assess its efficacy as an anti-tussive agent.

Biochem/physiol Actions

Na⁺ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration.

Na⁺ channel blocker; class IB antiarrhythmic.

General description

Lidocaine is an amide anesthetic, which is used to treat ventricular arrhythmias. It lowers cardiac automaticity and myocardial conduction. Lidocaine inhibits the generation and conduction of nerve impulses. It has an anticonvulsant effect.

Packaging

Supplied in amber screw-cap vials

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Key Issues in Plastic and Cosmetic Surgery (1999)

Pharmacological approaches that slow lymphatic flow as a snakebite first aid

van Helden DF, et al.

PLoS Neglected Tropical Diseases, 8(2), e2722-e2722 (2014)

Use of within-group designs to test anti-tussive drugs in conscious guinea-pigs

Venkatasamy R, et al.

Journal of Pharmacological and Toxicological Methods, 61(2), 157-162 (2010)

Effect of lidocaine on ventricular arrhythmias in patients with coronary heart disease

Gianelly R, et al.

The New England Journal of Medicine, 277(23), 1215-1219 (1967)

Seizures in Critical Care: A Guide to Diagnosis and Therapeutics (2008)

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