L8000

L-Leucine

Name: <SC>L</SC>-Leucine
Brand: SIGMA

≥98% (HPLC), suitable for ligand binding assays

Synonym(s):

(S)-2-Amino-4-methylpentanoic acid

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About This Item

Linear Formula:

(CH₃)₂CHCH₂CH(NH₂)CO₂H

CAS Number:

61-90-5

Molecular Weight:

131.17

NACRES:

NA.26

PubChem Substance ID:

24896488

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

200-522-0

MDL number:

MFCD00002617

Beilstein/REAXYS Number:

1721722

Product Name

L-Leucine, reagent grade, ≥98% (HPLC)

InChI key

ROHFNLRQFUQHCH-YFKPBYRVSA-N

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

SMILES string

CC(C)C[C@H](N)C(O)=O

grade

reagent grade

assay

≥98% (HPLC)

form

powder

technique(s)

ligand binding assay: suitable

impurities

isoleucine and methionine, essentially free

color

white to off-white

mp

>300 °C (lit.)

application(s)

peptide synthesis

Quality Level

200

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Related Categories

Chemistry & Biochemicals

Amino Acids

Amino Acids, Resins & Reagents for Peptide Synthesis

Biochemicals

Cell Culture Supplements & Reagents

Application

L-Leucine has been used as an agonist of mechanistic target of rapamycin (mTOR) to determine whether AMPK/mTOR pathway is involved in berberine-mediated autophagy in J774A.1 cells. It has also been used for the selection of transformed cells.

Biochem/physiol Actions

Leucine is a non-glucogenic, essential amino acid. It is a branched-chain amino acid that is a structural component of proteins. Leucine positively influences insulin release to eliminate toxic sugars out of the blood. The degradation of leucine leads to the formation of ketone bodies.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Bio-protocol (2017)

Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway

Xiaodi Fan

Journal of Translational Medicine (2015)

Dr. Victor Prisk

The Leucine Factor Diet: The Scientifically-Proven Approach to Combat Sugar, Burn Fat and Build Muscle (2015)

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