N4779
5-Nitro-2-(3-phenylpropylamino)benzoic acid
≥98%, chloride channel blocker, solid
Synonym(s):
NPPB
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About This Item
Empirical Formula (Hill Notation):
C16H16N2O4
CAS Number:
Molecular Weight:
300.31
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
5-Nitro-2-(3-phenylpropylamino)benzoic acid, ≥98%
Quality Level
assay
≥98%
form
solid
solubility
ethanol: 3 mg/mL, DMSO: 37 mg/mL, H2O: insoluble
storage temp.
−20°C
SMILES string
OC(=O)c1cc(ccc1NCCCc2ccccc2)[N+]([O-])=O
InChI
1S/C16H16N2O4/c19-16(20)14-11-13(18(21)22)8-9-15(14)17-10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11,17H,4,7,10H2,(H,19,20)
InChI key
WBSMIPAMAXNXFS-UHFFFAOYSA-N
Biochem/physiol Actions
Potent chloride channel blocker.
Features and Benefits
This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Michael R Bristow et al.
JACC. Basic to translational science, 5(9), 871-883 (2020-08-25)
Using serial analysis of myocardial gene expression employing endomyocardial biopsy starting material in a dilated cardiomyopathy cohort, we show that mRNA expression of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) cardiac myocyte receptor ACE2 is up-regulated with remodeling and with reverse
Agnieszka Dyrda et al.
PloS one, 5(2), e9447-e9447 (2010-03-03)
The mechanical, rheological and shape properties of red blood cells are determined by their cortical cytoskeleton, evolutionarily optimized to provide the dynamic deformability required for flow through capillaries much narrower than the cell's diameter. The shear stress induced by such
Anaïs Merckx et al.
PLoS pathogens, 4(2), e19-e19 (2008-02-06)
Malaria symptoms occur during Plasmodium falciparum development into red blood cells. During this process, the parasites make substantial modifications to the host cell in order to facilitate nutrient uptake and aid in parasite metabolism. One significant alteration that is required