SML3220
GSK923295
≥95% (HPLC)
Synonym(s):
3-Chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide, GSK 923295, GSK 923295A
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About This Item
Empirical Formula (Hill Notation):
C32H38ClN5O4
CAS Number:
Molecular Weight:
592.13
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
Quality Segment
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
Clc1c(ccc(c1)C(=O)N[C@H](CNC(=O)CN(C)C)Cc2ccc(cc2)c3nc4[n](c3)C=CC=C4[C@@H](O)C)OC(C)C
InChI key
WHMXDBPHBVLYRC-OFVILXPXSA-N
Biochem/physiol Actions
GSK923295 is an allosteric inhibitor of CENP-E kinesin motor ATPase activity. It inhibits release of inorganic phosphate and stabilizes CENP-E motor domain interaction with microtubules, which causes failure of metaphase chromosome alignment and induces mitotic arrest. GSK923295 induces tumor cell apoptosis and tumor regression
Selective and potent allosteric inhibitor of CENP-E kinesin motor ATPase activity
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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