440744
Polycaprolactone
average Mn 80,000
Greener Alternative
Synonym(s):
2-Oxepanone homopolymer, 6-Caprolactone polymer
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About This Item
Linear Formula:
(C6H10O2)n
UNSPSC Code:
12162002
NACRES:
NA.23
form
pellets (~3 mm)
Quality Segment
mol wt
average Mn 80,000
sustainability
Sustainability features
impurities
<0.5% water
color
white to off-white
mp
60 °C (lit.)
density
1.145 g/mL at 25 °C
Mw/Mn
<2
application(s)
3D bioprinting
advanced drug delivery
SMILES string
C1CCC(=O)OCC1 (Canonical-SMILES)
InChI
1S/C6H10O2/c7-6-4-2-1-3-5-8-6/h1-5H2
InChI key
PAPBSGBWRJIAAV-UHFFFAOYSA-N
General description
Polycaprolactone (PCL) is a semi crystalline hydrophobic biodegradable polyester which finds major applications as a drug delivery agent because of its cost efficiency, high toughness and biocompatibility. PCL possesses some unique properties such as:
- It degrades slower than other biodegradable polyesters in physiological condition, this property can be exploited in the controlled release of drugs in target tissues over a period of time.
- Its poor surface wetting and interaction with biological fluids on account of its hydrophobicity leads to poor cell adhesion and proliferation, hence it is blended with other synthetic /natural polymers.
This is an enabling product that belongs to a family of high-performance bio-based polymers that are essential for developing efficient, low-cost, and environmentally friendly renewable energy solutions. Click here for more information.
Application
- PCL loaded with antibiotics may be used to treat infections of the respiratory tract, like tuberculosis.
- Investigations were carried out based upon phenotypic responses of human bone marrow mesenchymal cells (hBMSCs) for different ratio of chitosan/ polycaprolactone (PCL) blends.
- PCL/biomedical ceramic materials have been studied for possible osteo tissue regeneration.
- Action of PCL/graded insulin/beta-5 glycerophosphate concentrations on osteochondral tissue formation through adipose-derived stromal cell differentiation.
- Other general uses include:extrusion aid, die lubricant, mold release, pigment and filler dispersion aid and polyester segments in urethanes and block polyesters.
Features and Benefits
Biodegradable polymer
Non-toxic, biodegradable in soil, broad miscibility, mechanical compatibility with many polymers and good adhesion to a broad spectrum of substrates.
Non-toxic, biodegradable in soil, broad miscibility, mechanical compatibility with many polymers and good adhesion to a broad spectrum of substrates.
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Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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