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764817

Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide)

average Mn (1100-1000-1100), lactide:glycolide 75:25

Synonym(s):

PLGA-PEG-PLGA

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About This Item

NACRES:
NA.23
UNSPSC Code:
12162002
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description

typical PEG PDI<1.1; overall PDI≤2.0 (THF, PS)

Quality Segment

100

form

semisolid

feed ratio

lactide:glycolide 75:25

mol wt

PEG average Mn 1,000, PLGA average Mn 2,200, average Mn (1100-1000-1100)

degradation timeframe

2-3 weeks

transition temp

Tm 230-235 °C

PDI

<2.0

storage temp.

2-8°C

General description

PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs.

Application

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.

Features and Benefits

Biocompatible, degradable, thermosensitive, high stability, small size (<200 nm) and properties can be easily modified.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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