902314
[CpRu(Fmoc-tyrosin)]CF3CO2
Synonym(s):
Fmoc-protected ruthenium tyrosine amino acid derivative, Peptide radiolabel precursor, [18F]Fluorophenylalanine peptide residue precursor
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C31H26F3NO7Ru
Molecular Weight:
682.61
UNSPSC Code:
12352209
NACRES:
NA.26
form
powder
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
mp
>300 °C
application(s)
peptide synthesis
functional group
Fmoc
storage temp.
2-8°C
SMILES string
O[C]1[CH][CH][C](CC(NC(OCC2C(C=CC=C3)=C3C4=C2C=CC=C4)=O)C(O)=O)[CH][CH]1.F[C-](F)F.O=C=O.[Ru+].c5cccc5
Application
The Ritter lab has developed a new method for direct labeling of polypeptides with the [18F]fluoride radiolabel. This Fmoc-protected ruthenium tyrosine is first incorporated into peptides, which is amenable to standard solid-phase peptide synthesis (SPPS) and is tolerant of all 20 canonical amino acids. Subsequent replacement of a single hydrogen with fluorine-18, with only minimal perturbation of the peptide structure, results in a site-specific, radiolabeled peptide tracer for use with positron emission tomography (PET) imaging in the study of various biological applications.
Legal Information
Patent Application EP18204755.5
This product is manufactured pursuant to a license with Studiengesellschaft Kohle mbH
This product is manufactured pursuant to a license with Studiengesellschaft Kohle mbH
Disclaimer
Research quantities limited to 10 g.
wgk
WGK 3
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.