907375
H-L-Photo-methionine HCl
≥95%
Synonym(s):
(S)-2-Amino-4-(3-methyl-3H-diazirin-3-yl)butanoic acid hydrochloride, (S)-2-Amino-4-(3H-diazirin-3-yl)pentanoic acid hydrochloride, Diazirine amino acid, Photo-Met, Photo-crosslinking amino acid, Photoprobe building block
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C6H12ClN3O2
CAS Number:
Molecular Weight:
193.63
UNSPSC Code:
12352209
assay
≥95%
form
powder
reaction suitability
reaction type: solution phase peptide synthesis
availability
available only in USA
application(s)
peptide synthesis
storage temp.
2-8°C
Application
H-L-Photo-Methionine HCl is a diazirine-containing methionine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (~360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An Fmoc-protected version is also available as 907367.
Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)
Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)
Other Notes
Carboxyl-Photo-Reactive MS-Cleavable Cross-Linkers: Unveiling a Hidden Aspect of Diazirine-Based Reagents
A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancer
Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes
Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe
Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells
Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis
Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)
A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancer
Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes
Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe
Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells
Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis
Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)
signalword
Danger
hcodes
Hazard Classifications
Self-react. C
Storage Class
5.2 - Organic peroxides and self-reacting hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Yeolin Lee et al.
Analytical chemistry, 88(19), 9503-9509 (2016-09-01)
Fc-specific antibody binding proteins (FcBPs) with the minimal domain of protein G are widely used for immobilization of well-oriented antibodies onto solid surfaces, but the noncovalently bound antibodies to FcBPs are unstable in sera containing large amounts of antibodies. Here
Claudio Iacobucci et al.
Analytical chemistry, 90(4), 2805-2809 (2018-01-30)
A major challenge in cross-linking/mass spectrometry (MS) is targeting carboxyl functions in proteins under physiological conditions that do not disturb the protein's conformation. Cross-linking of glutamic acid and aspartic acid residues in proteins will greatly expand the scope of structural
Michael J Bollong et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(46), E9903-E9912 (2017-11-01)
Expression of the transcription factor FOXC2 is induced and necessary for successful epithelial-mesenchymal transition, a developmental program that when activated in cancer endows cells with metastatic potential and the properties of stem cells. As such, identifying agents that inhibit the