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1.08212

Parteck® PLX 188 (Poloxamer 188)

(stabilized with 70ppm BHT), EMPROVE® ESSENTIAL, Ph. Eur., ChP, NF

Synonym(s):

Poloxamer 188

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About This Item

Linear Formula:
(C3H6O · C2H4O)x
CAS Number:
9003-11-6
UNSPSC Code:
12352112
MDL number:
MFCD00082049
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biological source

synthetic

Quality Level

500

agency

ChP, NF, Ph. Eur.

product line

EMPROVE® ESSENTIAL

bp

>150 °C

mp

55 °C

bulk density

1050 kg/m3

storage temp.

2-25°C

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

General description

With formulation challenges in mind, we have used particle engineering technologies to develop functional excipients specifically for solid oral dosage forms. The products in our Parteck® portfolio feature unique particle properties tailored for excellent performance in tableting processes, for specific drug delivery technologies, or for solubility enhancement.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Parteck® PLX 188 excipient combines adequate lubrication at tolerable concentrations with the added benefit of dissolution enhancement. It features consistent performance, improved dissolution rate and reliable lubrication – all at the same time. As a result, Parteck® PLX 188 excipient can therefore provide a simple solution to low bioavailability of DCS 2a compounds.

Features and Benefits

  • Hydrophilic, water-soluble tablet lubrication
  • Improved dissolution rates for poorly soluble DCS class IIa molecules
  • Specified particle size distribution optimized for solid application performance
  • Regulatory support through compliance with Ph. Eur. and USP-NF, going beyond current requirements with specitied formaldehyde content

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

>302.0 °F

flash_point_c

> 150 °C

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Articles

API Solubility and Dissolution Enhancement Via Formulation

Our overview of API solubility and dissolution enhancement methods can help you decide between the many options to take during formulation.

Global Trade Item Number

SKUGTIN
1.08212.902504061841048671
1.08212.050004061841048657
1.08212.000104061841048640