5.09708
SKF-97541
Synonym(s):
SKF-97541, GABA B Receptor Agonist, SKF-97541, SKF 97541, CGP 35024, 3-APMPA
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About This Item
Empirical Formula (Hill Notation):
C4H12NO2P
CAS Number:
Molecular Weight:
137.12
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (TLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
assay
≥98% (TLC)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
water: 100 mM
storage temp.
2-8°C
SMILES string
[P](=O)(O)(CCC[N+H3])C
InChI
1S/C4H12NO2P/c1-8(6,7)4-2-3-5/h2-5H2,1H3,(H,6,7)/p+1
InChI key
NHVRIDDXGZPJTJ-UHFFFAOYSA-O
General description
A highly potent agonist of GABAB receptor. Depresses excitatory postsynaptic potentials mediated by glutamate in the striatum, and hyperpolarized neurones in the substantia nigra (IC50 = 92 nM). Shown to be about 10-times more potent than baclofen (Cat. No. 505873). Induces vasodepression in pulmonary vascular bed that is modulated by an ATP-sensitive K+ channel. Induces gastric acid secretion in a dose-dependent manner (0.01 - 3 mg/kg, i.v.) in mice.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Primary Target
GABAB
GABAB
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Kaye, A.D., et al. 2004. Anesth. Analg.99, 758.
Piqueras, L., and Martinez, V. 2004. Br. J. Pharmacol.142, 1038.
Seabrook, G.R., et al. 1990. Br. J. Pharmacol.101, 949.
Piqueras, L., and Martinez, V. 2004. Br. J. Pharmacol.142, 1038.
Seabrook, G.R., et al. 1990. Br. J. Pharmacol.101, 949.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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