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Merck

IM1014

Anti-Matriptase/MT-SP1 Rabbit pAb

liquid, Calbiochem®

Synonym(s):

Anti-Membrane-Type Serine Protease 1, Anti-Suppressor of Tumorgenicity 14

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-Matriptase/MT-SP1 Rabbit pAb, liquid, Calbiochem®

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

liquid

contains

≤0.1% sodium azide as preservative

species reactivity

human

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

dilution

(Immunoblotting (1:500-1:2000)
Immunoprecipitation (5-20 µg/mg lysate))

isotype

IgG

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ST14(6768)

Analysis Note

Positive Control
MCF-7 cells

Application


Immunoblotting (1:500-1:2000)
Immunoprecipitation (5-20 g/mg lysate)

Disclaimer

Toxicity: Highly Toxic (H)

General description

Immunoaffinity purified rabbit polyclonal antibody. Recognizes the ~75 kDa matriptase protein.
Recognizes the ~75 kDa matriptase protein in MCF-7 cells.
This Anti-Matriptase/MT-SP1 Rabbit pAb is validated for use in Immunoblotting, Immunoprecipitation for the detection of Matriptase/MT-SP1.

Immunogen

Human
a synthetic peptide corresponding to amino acids near the C-terminus of human matriptase

Other Notes

Antibody should be titrated for optimal results in individual systems.
Santin, A.D., et al. 2003. Cancer98, 1898.
Takeuchi, T., et al. 2000. J. Biol. Chem.275, 26333.
Lin, C.Y., et al. 1999. J. Biol. Chem.274, 18231.
Takeuchi, T., et al. 1999. Proc. Natl. Acad. Sci. USA96, 11054.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In Tris-citrate/phosphate buffer, pH 7.0-8.0.

Preparation Note

Following initial use, aliquot and freeze (-20°C) for long-term storage. Avoid freeze/thaw cycles.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Marguerite S Buzza et al.
The Journal of biological chemistry, 292(26), 10801-10812 (2017-05-12)
Compromised gastrointestinal barrier function is strongly associated with the progressive and destructive pathologies of the two main forms of irritable bowel disease (IBD), ulcerative colitis (UC), and Crohn's disease (CD). Matriptase is a membrane-anchored serine protease encoded by suppression of
Sine Godiksen et al.
The Biochemical journal, 413(2), 251-259 (2008-04-12)
HAI-1 [HGF (hepatocyte growth factor) activator inhibitor-1] is a Kunitz-type transmembrane serine protease inhibitor that forms inhibitor complexes with the trypsin-like serine protease, matriptase. HAI-1 is essential for mouse placental development and embryo survival and together with matriptase it is
Sine Godiksen et al.
PloS one, 8(10), e77146-e77146 (2013-11-10)
Matriptase is a member of the family of type II transmembrane serine proteases that is essential for development and maintenance of several epithelial tissues. Matriptase is synthesized as a single-chain zymogen precursor that is processed into a two-chain disulfide-linked form
Jennifer M Milner et al.
Arthritis and rheumatism, 62(7), 1955-1966 (2010-05-28)
Increasing evidence implicates serine proteinases in pathologic tissue turnover. The aim of this study was to assess the role of the transmembrane serine proteinase matriptase in cartilage destruction in osteoarthritis (OA). Serine proteinase gene expression in femoral head cartilage obtained
Stine Friis et al.
The Journal of biological chemistry, 286(7), 5793-5802 (2010-12-15)
The matriptase-prostasin proteolytic cascade is essential for epidermal tight junction formation and terminal epidermal differentiation. This proteolytic pathway may also be operative in a variety of other epithelia, as both matriptase and prostasin are involved in tight junction formation in
View All Related Papers

Global Trade Item Number

SKUGTIN
IM1014-50UGCN04055977228175

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