PHI90009
Des-Ile(12)-Tirzepatide
GLP-1 Agonist Impurity, analytical standard, Numbering in the name as per API
Synonym(s):
Des-Ile(18)-Tirzepatide, H-Tyr-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Aib-Leu-Asp-Lys-Ile-Ala-Gln-Lys(AEEAc-AEEAc-γ-Glu-18-carboxy nonadecanoyl)-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
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About This Item
Empirical Formula (Hill Notation):
C219H337N47O67
Molecular Weight:
4700.29
UNSPSC Code:
41116107
grade
analytical standard
Quality Segment
API family
tirzepatide, tirzepatide, tirzepatide, tirzepatide
form
solid
technique(s)
HPLC: suitable, LC/MS: suitable, liquid chromatography (LC): suitable, mass spectrometry (MS): suitable
format
neat
General description
Des-Ile(12)-Tirzepatide is a deletion impurity of Tirzepatide—a dual GIP/GLP-1 receptor agonist—in which Isoleucine at position 12 (API numbering; position 12 in GIP/GLP-1 numbering) is absent, yielding a 38-residue peptide. Tirzepatide contains the non-standard residues Tyr1 and Aib2 at the N-terminus, and carries an AEEAc-AEEAc-γGlu-C20 fatty diacid conjugate at Lys19 (API numbering). The deletion of Ile12, located within the central helical segment critical for receptor binding, may significantly disrupt the conformational alignment required for dual GIP and GLP-1 receptor engagement. This impurity may arise during SPPS as a deletion sequence or from incomplete coupling of the sterically hindered Ile residue.
Application
Used as an analytical standard for the identification and semi-quantification of the des-Ile-12 deletion impurity in Tirzepatide API by RP-HPLC and LC-MS/MS. Supports impurity profiling and SPPS process development.
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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