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Merck

C6499

CTB

≥98% (HPLC)

Synonym(s):

CTPB, N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide

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About This Item

Empirical Formula (Hill Notation):
C16H13ClF3NO2
CAS Number:
451491-47-7
Molecular Weight:
343.73
MDL number:
MFCD02356522
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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Product Name

CTB, ≥98% (HPLC)

InChI key

YDXZSNHARVUYNM-UHFFFAOYSA-N

SMILES string

FC(F)(F)c1c(ccc(c1)NC(=O)c2c(cccc2)OCC)Cl

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

Quality Level

100

Application

CTB has been used to study its apoptotic effects on P53 protein acetylation.

Biochem/physiol Actions

CBP (CREB binding protein)/p300) histone acetyltransferases (HATs) activator; p300 HAT activator.
CTPB was a first known small molecular activator of histone acetyltransferase p300. CTB is a simplified analog of CTPB with comparable or higher activity. The compound activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein.
Small molecule activators of HAT such as CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is useful for altering chromatin acetylation directly. It might serve as a therapeutic agent for treating the complications of cognitive dysfunction including neuropsychiatric, neurodevelopmental and neurodegenerative diseases.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

General description

CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is derived from anacardic acid.

Storage Class

11 - Combustible Solids

wgk

WGK 2

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Certificates of Analysis (COA)

Lot/Batch Number
0000139964
0000139964
0000188878
0000188878
0000125193

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Cory Chew et al.
Neurorehabilitation and neural repair, 33(8), 656-667 (2019-07-10)
Background. Motoneuron loss is a severe medical problem that can result in loss of motor control and eventually death. We have previously demonstrated that partial motoneuron loss can result in dendritic atrophy and functional deficits in nearby surviving motoneurons, and
DeMetris D Reed et al.
Meat science, 123, 205-210 (2016-10-19)
Palatability attributes of beef striploin steaks mechanically enhanced with pork fat were evaluated. Striploins were collected from USDA Standard steer carcasses, longitudinally cut into halves (lateral or medial) and assigned randomly to pork fat injection (PFI) or non-injected control (CON).
The effect of CTB on P53 protein acetylation and consequence apoptosis on MCF-7 and MRC-5 cell lines
Dastjerdi MN, et al.
Advanced Biomedical Research, 2 (2013)
Franklin D Echevarria et al.
Frontiers in neuroscience, 11, 318-318 (2017-06-18)
The pleotropic cytokine interleukin-6 (IL-6) is implicated in retinal ganglion cell (RGC) survival and degeneration, including that associated with glaucoma. IL-6 protects RGCs from pressure-induced apoptosis
2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, 2 (2013)
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