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Merck

D7693

Dynasore hydrate

≥97.5% (HPLC), powder, dynamin 1 and dynamin 2 GTPase activity inhibitor

Synonym(s):

3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide hydrate

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About This Item

Empirical Formula (Hill Notation):
C18H14N2O4 · xH2O
CAS Number:
1202867-00-2
Molecular Weight:
322.31 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329798784
NACRES:
NA.77
MDL number:
MFCD11045288
Form:
powder
Quality level:
100
Storage condition:
protect from light

Key Documents

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Product Name

Dynasore hydrate,

SMILES string

O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O

InChI key

FKWZHQSDBMSHTN-ZIOFAICLSA-N

InChI

1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;

form

powder

storage condition

protect from light

color

off-white

solubility

DMSO: ≥10 mg/mL, H2O: insoluble

storage temp.

−20°C

Quality Level

100

Related Categories

General description

Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.

Application

Dynasore hydrate has been used:
  • for priming fetal mesenchymal stem/stromal cells (fMSC)
  • in confocal microscopy
  • in wound healing/scratch and tube-formation assay
  • to analyse its effects on Coxsackievirus A9 (CAV9) infection
  • to inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosis
  • in live imaging of cells

Biochem/physiol Actions

Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H400

pcodes

P273

Hazard Classifications

Aquatic Acute 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000513409
0000513409
0000454894
0000454894
0000418253

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Dynasore-not just a dynamin inhibitor
Preta G, et al.
Cell communication and signaling : CCS, 13(1), 24-24 (2015)
Florian Ehlgen et al.
PloS one, 7(6), e38781-e38781 (2012-06-22)
Haemoglobin degradation during the erythrocytic life stages is the major function of the food vacuole (FV) of Plasmodium falciparum and the target of several anti-malarial drugs that interfere with this metabolic pathway, killing the parasite. Two multi-spanning food vacuole membrane
Dynasore disrupts trafficking of HSV proteins
Mues MB, et al.
Journal of Virology, JVI-00636 (2015)
G J Hofmeyr et al.
BJOG : an international journal of obstetrics and gynaecology, 121(8), 951-957 (2014-03-14)
Epidemiological data link low dietary calcium with pre-eclampsia. Current recommendations are for 1.5-2 g/day calcium supplementation for low-intake pregnant women, based on randomised controlled trials of ≥1 g/day calcium supplementation from 20 weeks of gestation. This is problematic logistically in
Radioimmunotherapy of fibroblast activation protein positive tumors by rapidly internalizing antibodies
Fischer E, et al
Clinical Cancer Research, clincanres-clinca0644 (2012)
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