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Merck

08-115

Rat Collagen Type I

from rat tail, liquid, 2-5 mg/mL, suitable for cell culture, used for 3D gel formation

동의어(들):

Rat tail collagen, Rat tail collagen type I

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.75
Biological source:
rat
Form:
liquid, solution
Technique(s):
cell culture | mammalian: suitable (and for 3D proliferation assays.)
Concentration:
100 mg

주요 문서

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제품 이름

Collagen Type I, rat tail, 100 mg, solution, BioReagent, suitable for cell culture

form

liquid, solution

biological source

rat

manufacturer/tradename

Upstate®

concentration

100 mg

technique(s)

cell culture | mammalian: suitable (and for 3D proliferation assays.)

input

sample type hematopoietic stem cell(s)
sample type mesenchymal stem cell(s)
sample type induced pluripotent stem cell(s)
sample type epithelial cells
sample type pancreatic stem cell(s)
sample type neural stem cell(s)
sample type: mouse embryonic stem cell(s)

NCBI accession no.

NM_000088.3

UniProt accession no.

P02452

shipped in

wet ice

storage temp.

2-8°C

Quality Level

100

Gene Information

rat ... COL1A1(29393)

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관련 카테고리

General description

In humans, type I collagen is the most abundant and broadly expressed collagen. This heterotrimer contains two alpha 1 (I) chains and one alpha 2 (I) chain. Collagen type I α 1 (COL1A1), a major component of collagen type I, codes for pro-α 1 chains of type I collagen. It has repeating Gly-Xaa-Yaa tri-peptides motifs. The collagen alpha-1(I) chain protein is a member of the collagen complex superfamily. COL1A1 has a von Willebrand factor type C (vWFC) domain, a collagen triple-helix repeat, and a fibrillar collagen C-terminal domain (COLF).

Application

Collagen Type I, rat tail has been used:
  • for collagen 3D proliferation assays
  • for atelocollagen proliferation assays
  • in a comparative study to make microcapsules for templating on mesoporous cores of pure vaterite calcium carbonate (CaCO3) crystals to evaluate the structure-property relationship
  • in coverslip coating to grow the human cerebral microvascular endothelial cell line (hCMEC/D3) for creating a cell coculture and chronic subdural hematoma (CSDH) patient hematoma sample induced injury model

Biochem/physiol Actions

Collagen type I α 1 (COL1A1) plays a key role in chemoresistance and may act as a therapeutic target. It is involved in carboplatin-resistant ovarian cancer (OV). COL1A1 serves as an oncogene in the development of colorectal cancer (CRC). Dominant inherited COL1A1 gene mutations result in connective tissue disorders such as osteogenesis imperfecta (OI).

Physical form

0.02N acetic acid, pH 3.67

Preparation Note

1 year at 4°C

Analysis Note

Routinely evaluated by testing for uniform gelation and for attachment of and spreading of PC-12 rat cells

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

저장 등급

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

시험 성적서(COA)

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