178251
α1-Antitrypsin, Human Plasma
α1-Antitrypsin, CAS 9041-92-3, is a protease inhibitor of the serpin superfamily. Inhibits elastase, cathepsin G, and proteinase 3.
동의어(들):
α1-Antitrypsin, Human Plasma, α1-AT, α1-Proteinase Inhibitor, 3.5S α1-Glycoprotein
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제품정보 (DICE 배송 시 비용 별도)
Assay:
≥95% (SDS-PAGE)
Form:
solid
Storage condition:
OK to freeze
Quality Segment
description
Merck USA index - 14, 719
assay
≥95% (SDS-PAGE)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
water: soluble
shipped in
ambient
storage temp.
−20°C
General description
A single polypeptide chain of 394 amino acids and three carbohydrate side chains linked to asparagine residues present at about 290 mg/100 ml in acute phase plasma. Serine protease inhibitor that also acts as a major physiological regulator of elastase. Inhibitor of neutrophil elastase, cathepsin G, and proteinase 3.
Biochem/physiol Actions
Cell permeable: no
Primary Target
serine proteases
serine proteases
Product does not compete with ATP.
Reversible: no
Physical form
Lyophilized from 300 mM NaCl, 30 mM sodium phosphate buffer, pH 6.5.
Preparation Note
Following reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
Please refer to vial label for lot-specific volume prior to lyophilization.
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Analysis Note
>=75% inhibition with active-site titrated porcine trypsin using benzoyl-Arg-p-nitroanilide (Bz-Arg-pNA) as the substrate.
Other Notes
Coakley, R.J., et al. 2001. Am. J. Med. Sci.321, 33.
Travis, J., and Salvesen, G.S. 1983. Annu. Rev. Biochem.52, 655.
Travis, J., and Salvesen, G.S. 1983. Annu. Rev. Biochem.52, 655.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Toxicity: Standard Handling (A)
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
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