203297-M
Bisindolylmaleimide IV
A potent, cell permeable, and selective inhibitor of protein kinase C (IC50 = 87 nM).
동의어(들):
Bisindolylmaleimide IV, Arcyriarubin A, 2,3- bis(1H-Indol-3-yl)maleimide, Ro 31-6233
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C20H13N3O2
CAS 번호:
Molecular Weight:
327.34
UNSPSC Code:
12352111
MDL number:
NACRES:
NA.77
Assay:
≥98% (TLC)
Form:
powder, solid
Storage condition:
OK to freeze
Quality Segment
assay
≥98% (TLC)
form
powder, solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
dark orange
solubility
methanol: 10 mg/mL
storage temp.
2-8°C
SMILES string
N1C(=O)C(=C(C1=O)c4c5c([nH]c4)cccc5)c2c3c([nH]c2)cccc3
InChI
1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
InChI key
DQYBRTASHMYDJG-UHFFFAOYSA-N
General description
A cell-permeable potent and selective inhibitor of protein kinase C (IC50 = 87 nM) and protein kinase A (IC50 = 2.7 µM).
A potent, cell permeable, and selective inhibitor of protein kinase C (IC50 = 87 nM). Inhibits protein kinase A at much higher concentrations (IC50 = 2.7 µM).
Biochem/physiol Actions
Primary Target
PKC
PKC
Target IC50: 87 nM against protein kinase C
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Fabre, S., et al. 1993. Bioorg. Med. Chem.1, 193.
Davis, P.D., et al. 1992. J. Med. Chem.35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
Davis, P.D., et al. 1992. J. Med. Chem.35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.