231085
Cilostamide
A cell-permeable selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 70 nM).
동의어(들):
Cilostamide, N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide, OPC 3689
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C20H26N2O3
CAS 번호:
Molecular Weight:
342.43
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (TLC)
Form:
solid
Storage condition:
OK to freeze
Quality Segment
assay
≥98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[nH]1c2c(cc[c]1=O)cc(cc2)OCCCC(=O)N(C3CCCCC3)C
InChI
1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
InChI key
UIAYVIIHMORPSJ-UHFFFAOYSA-N
General description
A cell-permeable selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 70 nM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PDE 3
PDE 3
Product does not compete with ATP.
Reversible: no
Target IC50: 70 nM against PDE III
Preparation Note
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
Other Notes
Verghese, M.W., et al. 1995. J. Pharmacol. Exp. Ther. 272, 1313.
Christensen, S.B., and Trophy, T.J. 1994. Ann. Rep. Med. Chem. 29, 185.
Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.
Christensen, S.B., and Trophy, T.J. 1994. Ann. Rep. Med. Chem. 29, 185.
Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable