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Merck

365250

Gö 6976

≥95% (HPLC), protein kinase C inhibitor, solid

동의어(들):

Gö 6976, Go 6976, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C24H18N4O
CAS 번호:
136194-77-9
Molecular Weight:
378.43
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00236434

주요 문서

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제품 이름

Gö 6976, Gö 6976, CAS 136194-77-9, is a cell-permeable, reversible, and ATP-competitive inhibitor of PKC (IC50 = 7.9 nM for rat brain). Exhibits selectively for PKCα (IC50 = 2.3 nM) and βI (IC50 = 6.2 nM).

SMILES string

[n]1(c2c3[n](c4c(c3c5c(c2c6c1cccc6)CNC5=O)cccc4)C)CCC#N

InChI

1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)

InChI key

VWVYILCFSYNJHF-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 5 mg/mL

shipped in

ambient

Quality Level

100

관련 카테고리

General description

A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC; IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKC α-isozyme (IC50 = 2.3 nM) and PKCβI (IC50 = 6.2 nM). Does not affect the kinase activity of the Ca2+-independent PKC δ-, ε-, and ζ-isozymes even at micromolar levels. Reported to inhibit PKCµ at higher concentrations (IC50 = 20 nM). A 500 µg/ml solution of Gö 6976 (Cat. No. 365253) in anhydrous DMSO is also available.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PKC
Product competes with ATP.
Reversible: yes
Target IC50: 7.9 nM against rat brain PKC; 2.3 nM, 6.2 nM against Ca2+-dependent PKC α-isozyme and PKCβI, respectively

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.
Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun.200, 1536.
Martiny-Baron, G.M., et al. 1993. J. Biol. Chem.268, 9194.
Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA90, 4674.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

시험 성적서(COA)

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문서

How to Use Inhibitors

Learn tips and tricks for how to properly use inhibitors including how to select the right inhibitor and how to plan experiments with inhibitors.

억제제 사용 방법

올바른 억제제를 선택하는 방법과 억제제를 사용한 실험을 계획하는 방법 등 억제제를 올바르게 사용하는 방법에 대한 팁과 요령을 알아보세요.

국제 무역 품목 번호

SKUGTIN
365250-1MGCN04055977192018
365250-500UGCN07790788049614

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