393204
4-Hydroxynonenal
≥98% (HPLC), liquid, lipid peroxidation marker, Calbiochem®
동의어(들):
4-Hydroxynonenal
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크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C9H16O2
CAS 번호:
Molecular Weight:
156.22
MDL number:
UNSPSC Code:
12352114
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
liquid
Storage condition:
OK to freeze
제품 이름
4-Hydroxynonenal, 4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation.
Quality Segment
description
RTECS - RA8510000
assay
≥98% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
ethanol: 10 mg/mL
storage temp.
−70°C
SMILES string
OC(CCCCC)\C=C\C=O
InChI
1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+
InChI key
JVJFIQYAHPMBBX-FNORWQNLSA-N
General description
4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation.
A major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages and in PC12 cells. An inhibitor of state 3 respiration at micromolar levels. Causes a transient increase in cytosolic Ca2+ and irreversibly inhibits Na+, K+-ATPase activity (IC50 = 120 µM). Acts as a reversible inhibitor of c-Jun N-terminal kinase (JNK).
A major aldehydic product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages. An inhibitor of State 3 respiration at micromolar levels that causes a transient increase in cytosolic Ca2+. Irreversibly inhibits Na+-K+-ATPase activity (IC50 = 120 µM).
Biochem/physiol Actions
Primary Target
Na+, K+-ATPase activity
Na+, K+-ATPase activity
Product does not compete with ATP.
Target IC50: 120 µM against Na+, K+-ATPase activity
Physical form
Supplied at 10 mg/ml in ethanol
Preparation Note
Following initial thaw, aliquot and freeze (-70°C).
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Soh, Y., et al. 2000. Mol. Pharmacol.58, 535.
Carini, R., et al. 1996. Biochem. Biophys. Res. Commun.218, 772.
Li, L., et al. 1996. Toxicol.Appl. Pharmacol.139, 135.
Siems, W.G., et al. 1996. Free Radic. Res.20, 215.
Ullrich, O., et al. 1996. Free Radic. Res.24, 421.
van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
Esterbauer, H., et al. 1991. Free Radic. Biol. Med.11, 81.
Carini, R., et al. 1996. Biochem. Biophys. Res. Commun.218, 772.
Li, L., et al. 1996. Toxicol.Appl. Pharmacol.139, 135.
Siems, W.G., et al. 1996. Free Radic. Res.20, 215.
Ullrich, O., et al. 1996. Free Radic. Res.24, 421.
van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
Esterbauer, H., et al. 1991. Free Radic. Biol. Med.11, 81.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Flammable (J)
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2
저장 등급
3 - Flammable liquids
wgk
WGK 3
flash_point_f
57.2 °F - closed cup
flash_point_c
14 °C - closed cup
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.