주요 문서

모든 문서 보기

573099

Stattic

Name: Stattic
Brand: MM

≥95% (HPLC), STAT3 inhibitor, solid

동의어(들):

STAT3 Inhibitor V, Stattic, 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

보기 변경

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₈H₅NO₄S

CAS 번호:

19983-44-9

Molecular Weight:

211.19

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00173799

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

기술 서비스

도움이 필요하신가요? 저희 숙련된 과학자 팀이 도와드리겠습니다.

도움 문의

속성

제품 이름

STAT3 Inhibitor V, Stattic, STAT3 Inhibitor V, Stattic, CAS 19983-44-9, is a cell-permeable inhibitor of STAT3 cellular function that targets the STAT3-SH2 domain and prevents its association with upstream Kinases.

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

pale yellow

solubility

DMSO: 10 mg/mL, ethanol: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S]1(=O)(=O)c2c(ccc(c2)[N+](=O)[O-])C=C1

InChI

1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H

InChI key

ZRRGOUHITGRLBA-UHFFFAOYSA-N

설명

General description

A cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr⁷⁰⁵ with little effect towards STAT1 phosphorylation at Tyr⁷⁰¹ (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
STAT3

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.

Other Notes

Schust, J., et al. 2006. Chem. Biol.13, 1235.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Still not finding the right product?

Explore all of our products under STAT3 Inhibitor V, Stattic

pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c