684500
Zaprinast - CAS 37762-06-4 - Calbiochem
A cell-permeable, selective inhibitor of cGMP-specific phosphodiesterase (PDE V; IC50 = 450 nM).
동의어(들):
Zaprinast - CAS 37762-06-4 - Calbiochem, 1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidine-7-one, M&B22948
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C13H13N5O2
CAS 번호:
Molecular Weight:
271.27
UNSPSC Code:
12352200
MDL number:
Quality Segment
assay
≥98% (HPLC)
form
solid
potency
450 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
tan to pink
solubility
DMSO: 25 mg/mL, ethanol: 5 mg/mL
shipped in
ambient
storage temp.
10-30°C
InChI
1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
InChI key
REZGGXNDEMKIQB-UHFFFAOYSA-N
General description
A cell-permeable, selective inhibitor of cGMP-specific phosphodiesterase (PDE V; IC50 = 450 nM). Inhibits PDE IX at higher concentration (IC50 = 35 µM). Also known to increase cGMP levels in spontaneously hypertensive rat (SHR) plasma and reverse nitroglycerin tolerance in vitro. Enhances the vasodilatory effects of nitric oxide.
Selective inhibitor of cGMP-specific phosphodiesterase (PDE V, IC50 = 450 nM). Also known to increase cGMP levels in SHR plasma and reverse nitroglycerin tolerance in vitro. Enhances the vasodilatory effects of nitric oxide.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
cGMP-specific phosphodiesterase
cGMP-specific phosphodiesterase
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
From Catalog:
Desc. Field- added "cell-permeable"
From Catalog:
Desc. Field- added "cell-permeable"
Other Notes
Fisher, D.A., et al. 1998. J. Biol. Chem. 273, 15559.
Tsusu, K.G., et al. 1995. Am. J. Respir. Crit. Care Med.152, 1605.
Dundore, R.L., et al. 1993. Eur. J. Pharmacol.249, 293.
Pagani, E.D., et al. 1993. Eur. J. Pharmacol.243, 141.
Burns, F., et al. 1992. Biochem. J.283, 487.
Lugnier, C., et al. 1992. Am. J. Physiol.262, H654.
Tsusu, K.G., et al. 1995. Am. J. Respir. Crit. Care Med.152, 1605.
Dundore, R.L., et al. 1993. Eur. J. Pharmacol.249, 293.
Pagani, E.D., et al. 1993. Eur. J. Pharmacol.243, 141.
Burns, F., et al. 1992. Biochem. J.283, 487.
Lugnier, C., et al. 1992. Am. J. Physiol.262, H654.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
저장 등급
10-13 - German Storage Class 10 to 13