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Merck

8.40124

Span® 85

for synthesis

동의어(들):

Span® 85, Sorbitan trioleate, (Z,Z,Z)-Sorbitan tri-9-octadecenoate

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C60H108O8
CAS 번호:
Molecular Weight:
957.49
UNSPSC Code:
12352108
EC Index Number:
247-569-3
NACRES:
NA.22
MDL number:
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vapor pressure

<1.4 hPa ( 20 °C)

Quality Segment

form

liquid

potency

39800 mg/kg LD50, oral (Rat)

kinematic viscosity

120 cSt(40 °C)

transition temp

flash point 225 °C

solubility

insoluble <0.001 g/L

density

0.95 g/cm3 at 20 °C

storage temp.

2-30°C

SMILES string

O1[C@@H]([C@H]([C@@H](C1)O)OC(=O)CCCCCCC\C=C/CCCCCCCC)C(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC

InChI

1S/C60H108O8/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-43-46-49-56(62)65-53-55(67-57(63)50-47-44-41-38-35-32-29-26-23-20-17-14-11-8-5-2)60-59(54(61)52-66-60)68-58(64)51-48-45-42-39-36-33-30-27-24-21-18-15-12-9-6-3/h25-30,54-55,59-61H,4-24,31-53H2,1-3H3/b28-25-,29-26-,30-27-/t54-,55?,59+,60-/m1/s1

InChI key

PRXRUNOAOLTIEF-XDTJCZEISA-N

Application


  • Macromolecular Stabilization: Span® 85 is used as a stabilizer for the preparation of PMMA colloidal particles in nonpolar media, proving effective in maintaining stability under various conditions, crucial for industrial applications in coatings and advanced materials manufacturing (Liu et al., 2022).

  • Enhanced Nanoemulsion Systems: It plays a critical role in the formation of aerosolized nanoemulsion systems encapsulating docetaxel and curcumin, utilized in cancer therapy to improve therapeutic outcomes through enhanced drug delivery mechanisms (Abdul Rahman et al., 2020).

  • Skin Protection Formulations: Span® 85 is integral in the formulation and clinical assessment of microemulsion-based hydrogels for UV protection, demonstrating its utility in skincare products by enhancing sun protection factor and skin compatibility (Ebrahimi et al., 2019).

  • Transdermal Drug Delivery: This surfactant is utilized in tailoring novel soft nano-vesicles, known as ′Flexosomes′, to enhance transdermal drug delivery, which is pivotal for non-invasive therapeutic applications and improving patient compliance (Mansour et al., 2019).

Analysis Note

Hydroxyl value: 55 - 75
Saponification value: 170 - 190
Identity (IR): passes test
Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.

Legal Information

Span is a registered trademark of Croda International PLC


저장 등급

10 - Combustible liquids

wgk

WGK 1

flash_point_f

437.0 °F

flash_point_c

225 °C



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