제품 이름
Anti-Vesicular Glutamate Transporter 1 Antibody, serum, Chemicon®
biological source
guinea pig
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
rat ... Slc17A7(116638)
Application
- Tested Applications
Immunocytochemistry Analysis: A 1:250 dilution from a representative lot detected Vesicular Glutamate Transporter 1 in rat E18 cortical cells. - Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
Biochem/physiol Actions
Recognizes Vesicular Glutamate Transporter 1 (VGLUT1, BNPI {Brain specific Na+ dependent inorganic phosphate cotransporter}). The antiserum has been tested on tissue sections from the rat central nervous system (CNS) using immunofluorescence histochemistry. The antiserum mainly labels nerve fibers and terminals. VGLUT1 is an excellent marker for glutamatergic nerve terminals. The staining pattern for the staining obtained with the VGLUT1 antiserum corresponds to the pattern described using other antisera to VGLUT1 (Bellocchio et al., 1998; Fremeau et al., 2001; Fujiyama et al., 2001; Sakata-Haga et al., 2001; Tong et al., 2001; Kaneko et al. 2002; Varoqui et al., 2002). Preabsorption of the VGLUT1 antiserum with immunogen peptide eliminates all immunostaining.
General description
62 kDa
Vesicular glutamate transporter 1 (VGLUT1) is encoded by the gene mapped to human chromosome 19q13. VGLUT1 is specifically expressed in neuronal cells in the brain. It is characterized with a conserved C-terminal dileucine-like motif and two polyproline domains distal to C- terminal end, including one that binds to endocytic BAR (Bin/Amphiphysin/Rvs) domain protein, endophilin.
Immunogen
Synthetic peptide from rat VGLUT1 protein with no overlap to VGLUT2. The immunogen is available as AG208.
Physical form
Guinea pig Serum in 0.1% Sodium Azide.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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저장 등급
10 - Combustible liquids
wgk
WGK 1
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Depletion of spinal 5-HT accelerates mechanosensory recovery in the deafferented rat spinal cord
Cragg JJ, et al.
Experimental Neurology, 222(2), 277-284 (2010)
Assignment of SLC17A6 (alias DNPI), the gene encoding brain/pancreatic islet-type Na+-dependent inorganic phosphate cotransporter to human chromosome 11p14.3
Aihara Y, et al.
Cytogenetics and Cell Genetics (2001)
Xia Chen et al.
PloS one, 6(2), e17072-e17072 (2011-03-02)
The success of transplants of neural tissue into the adult dentate gyrus in generating mature neurons is highly variable. Here we address the roles of the origin of the tissue and its pre-implantation preparation, and show that both are critical.
Activation of NMDA Receptors in Lumbar Spinothalamic Cells is Required for Ejaculation.
Staudt MD, de Oliveira CV, Lehman MN, McKenna KE, Coolen LM.
Journal of Sexual Medicine null
Lentiviral delivery of a vesicular glutamate transporter 1 (VGLUT1)-targeting short hairpin RNA vector into the mouse hippocampus impairs cognition
King MV, et al.
Neuropsychopharmacology, 39(2), 464-476 (2014)
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| AB5905 | 04053252333897 |
| AG208 | 04053252282812 |
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