MAB308
Anti-Dopamine β Hydroxylase Antibody, clone 4F10.2
ascites fluid, clone 4F10.2, Chemicon®
동의어(들):
DBH
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
4F10.2, monoclonal
Application:
immunofluorescence
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
Species reactivity:
rat, bovine, sheep
Citations:
122
Technique(s):
immunofluorescence: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
Uniprot accession no.:
제품 이름
Anti-Dopamine β Hydroxylase Antibody, clone 4F10.2, ascites fluid, clone 4F10.2, Chemicon®
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
4F10.2, monoclonal
species reactivity
rat, bovine, sheep
manufacturer/tradename
Chemicon®
technique(s)
immunofluorescence: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
bovine ... Dbh(280758)
rat ... Dbh(25699)
Analysis Note
Immunohistochemistry(paraffin): Dopamine β Hydroxylase (cat. # MAB308) staining pattern/morphology in rat spinal cord. Tissue was pretreated with Citrate, pH 6.0. This lot of antibody was diluted to 1:300, using IHC-Select Detection with HRP-DAB. Immunoreactivity is seen predominantly expressed in the dorsal root ganglia (DRG).
Optimal Staining With Citrate Buffer, pH 6.0, Epitope Retrieval: Rat Spinal Cord
Optimal Staining With Citrate Buffer, pH 6.0, Epitope Retrieval: Rat Spinal Cord
Application
Anti-Dopamine β Hydroxylase Antibody, clone 4F10.2 detects level of Dopamine β Hydroxylase & has been published & validated for use in IH, IH(P) & IF.
Indirect immunofluorescence:
1:300-1:500 dilution of a previous lot was used on rat brain tissue.
Optimal working dilutions must be determined by the end user.
Immunohistochemistry(paraffin):
Representative images from a previous lot.
Optimal Staining With Citrate Buffer, pH 6.0, Epitope Retrieval: Rat Spinal Cord
1:300-1:500 dilution of a previous lot was used on rat brain tissue.
Optimal working dilutions must be determined by the end user.
Immunohistochemistry(paraffin):
Representative images from a previous lot.
Optimal Staining With Citrate Buffer, pH 6.0, Epitope Retrieval: Rat Spinal Cord
Biochem/physiol Actions
Dopamine beta hydroxylase (DBH).
General description
Dopamine Beta Hydroxylase (DBH), the structural locus encoding DβH enzyme, is a major quantitative trait locus influencing plasma DβH activity, with one single nucleotide polymorphism (SNP) accounting for up to 50% of the variance. Mutations at DBH appear to be responsible for the rare syndrome of DβH deficiency. It functions as the only enzyme involved in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine and epinephrine the only transmitters synthesized inside vesicles. It is expressed in noradrenergic nerve terminals of the central and peripheral nervous systems, as well as in chromaffin cells of the adrenal medulla.
Immunogen
Purified bovine DBH.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: MAB394-250UG; MAB394-100UG; MAB394-25UG
Physical form
Ascites mouse monoclonal IgG1 in liquid with 0.1% sodium azide.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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저장 등급
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Differential activation of chemically identified neurons in the caudal nucleus of the solitary tract in non-entrained rats after intake of satiating vs. non-satiating meals.
Kreisler, AD; Davis, EA; Rinaman, L
Physiology & Behavior null
The rate of fall of blood glucose determines the necessity of forebrain-projecting catecholaminergic neurons for male rat sympathoadrenal responses.
Jokiaho, AJ; Donovan, CM; Watts, AG
Diabetes null
S Gutierrez et al.
Neuroscience, 228, 301-308 (2012-10-30)
Tissue and nerve damage can result in chronic pain. Yet, chronic pain after cesarean delivery is remarkably rare in women and hypersensitivity from peripheral nerve injury in rats resolves rapidly if the injury occurs in the puerperium. Little is known
Michael D Schwartz et al.
eNeuro, 3(2) (2016-03-30)
Hypocretin 1 and 2 (Hcrts; also known as orexin A and B), excitatory neuropeptides synthesized in cells located in the tuberal hypothalamus, play a central role in the control of arousal. Hcrt inputs to the locus coeruleus norepinephrine (LC NE)
Glucocorticoid enhancement of memory requires arousal-induced noradrenergic activation in the basolateral amygdala.
Roozendaal, B; Okuda, S; Van der Zee, EA; McGaugh, JL
Proceedings of the National Academy of Sciences of the USA null
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| MAB308 | 04053252577741 |
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