MAB4140
Anti-MDR3 Antibody, clone P3 II-26
culture supernatant, clone P3 II-26, Chemicon®
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
P3 II-26, monoclonal
Species reactivity:
human
Application:
ICC, IHC, WB
Citations:
9
biological source
mouse
antibody form
culture supernatant
antibody product type
primary antibodies
clone
P3 II-26, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable
isotype
IgG2b
suitability
not suitable for immunohistochemistry (Paraffin)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
Quality Level
Gene Information
human ... ABCB4(5244)
Immunogen
Mab was selected after immunization with a fusion protein consisting of Gluthatione-S-Transferase and a fragment of MDR3 P-gp comprising aa 629-692.
Application
Anti-MDR3 Antibody, clone P3 II-26 is an antibody against MDR3 for use in WB, IC, IH.
Western Blotting: MDR3 is a 140 kDa protein.
Immunocytochemistry: 1:20 - 1:50 on acetone-fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone-fixed frozen sections
Not suitable for paraffin-embedded tissues
Optimal working dilutions must be determined by end user.
Immunocytochemistry: 1:20 - 1:50 on acetone-fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone-fixed frozen sections
Not suitable for paraffin-embedded tissues
Optimal working dilutions must be determined by end user.
Biochem/physiol Actions
This antibody reacts with an internal epitope of MDR3 P-gp. It does not cross-react with the human MDR1 P-gp. It has been reported that this clone also cross reacts with mouse MDR2 Pgp {Kok et al 2003 {http://www.biochemj.org/bj/369/0539/3690539.pdf}.
Preparation Note
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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저장 등급
10 - Combustible liquids
wgk
WGK 2
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
G J Hooiveld et al.
Gastroenterology, 117(3), 678-687 (1999-08-28)
Biliary cholesterol secretion is coupled to that of phospholipids in a process controlled by mdr2 P-glycoprotein activity and bile salt secretion. Statins, the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, have been shown to affect hepatobiliary lipid secretion in rats. The aim
Tineke Kok et al.
The Biochemical journal, 369(Pt 3), 539-547 (2002-10-17)
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor that controls expression of genes involved in lipid metabolism and is activated by fatty acids and hypolipidaemic fibrates. Fibrates induce the hepatic expression of murine multidrug resistance 2 ( Mdr2 )
G L Scheffer et al.
Cancer research, 60(18), 5269-5277 (2000-10-04)
Tumor cells may display a multidrug resistance phenotype by overexpression of ATP binding cassette transporter genes such as multidrug resistance (MDR) 1 P-glycoprotein (P-gp) or the multidrug resistance protein 1 (MRP1). MDR3 P-gp is a close homologue of MDR1 P-gp
Maria Paprocka et al.
European journal of haematology, 99(5), 415-422 (2017-08-15)
It is well established that expression of multi-drug resistance (MDR) proteins (MDR1, BCRP, MDR3, MRP1, and LRP) in leukemic blasts correlates with acute myeloid leukemia (AML) patients' clinical response. Assuming that leukemic stem cells (LSC) are resistant to chemotherapy and
Denis A Evseenko et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 290(5), R1357-R1365 (2005-12-03)
ATP-binding cassette (ABC) efflux transporters are expressed in the human placenta where they are thought to help protect the fetus from xenobiotics. To evaluate models for analysis of ABC transporter function and regulation in the placenta, we have characterized the
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| MAB4140 | 04053252578908 |
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