MAB5284
Anti-Aggrecan Antibody
CHEMICON®, mouse monoclonal, Cat-301
동의어(들):
CSPG
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
Cat-301, monoclonal
Species reactivity:
primate, human, rat, gerbil, feline, hamster, guinea pig
Application:
ICC, IHC, IP, WB
Citations:
36
제품 이름
Anti-Chondroitin Sulfate Proteoglycan Antibody, Brain (core protein), clone Cat-301, clone Cat-301, Chemicon®, from mouse
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
Cat-301, monoclonal
species reactivity
primate, human, rat, gerbil, feline, hamster, guinea pig
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ACAN(176)
General description
The antigen recognized by this clone, CAT-301 is a proteoglycan that is developmentaly regulated, high molecular chondroitin sulphate proteoglycan found on the extracellular surface of mammalian neurons. It is expressed late in development and although no definitive role has been identified for CAT-301, it is believed to have a role in the stabilisation of synaptic structure.
The name derives from the name of the monoclonal antibody originally used to identified by its expression, which was detected immunocytochemicaly
Disruption of the normal patterns of neuronal activity during the critical early postnatal period by physical or biochemical means results in a large and irreversible reduction in levels of CAT-301. Similar intervention in mature animals has no effect
CAT-301 is related to aggrecan from articular cartilage. The CAT-301 antibody immunoreacts with aggrecan, and the chondroitinase treated aggrecan and CAT-301 both have apparent sizes of 550kDa. However CAT- 301 is not glycosylated by keratan sulphate, as aggrecan is.
The name derives from the name of the monoclonal antibody originally used to identified by its expression, which was detected immunocytochemicaly
Disruption of the normal patterns of neuronal activity during the critical early postnatal period by physical or biochemical means results in a large and irreversible reduction in levels of CAT-301. Similar intervention in mature animals has no effect
CAT-301 is related to aggrecan from articular cartilage. The CAT-301 antibody immunoreacts with aggrecan, and the chondroitinase treated aggrecan and CAT-301 both have apparent sizes of 550kDa. However CAT- 301 is not glycosylated by keratan sulphate, as aggrecan is.
Immunogen
Epitope: Brain (core protein)
Feline spinal cord fixed gray matter.
Application
Anti-Chondroitin Sulfate Proteoglycan Antibody, Brain (core protein), clone Cat-301 detects level of Chondroitin Sulfate Proteoglycan & has been published & validated for use in IP, WB, IC, IH.
Immunohistochemistry: 1:500-1:2,000 on 4% paraformaldehyde fixed frozen tissue.
Immunocytochemistry
Immunoblot
Immunoprecipitation
Optimal working dilutions must be determined by the end user.
Immunocytochemistry
Immunoblot
Immunoprecipitation
Optimal working dilutions must be determined by the end user.
Biochem/physiol Actions
Chondroitin sulfate proteoglycan (CSPG), brain core protein.
Physical form
Format: Purified
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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저장 등급
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Lena Iwai et al.
Cerebral cortex (New York, N.Y. : 1991), 23(9), 2204-2212 (2012-07-14)
Although the parallel visual pathways are a fundamental basis of visual processing, our knowledge of their molecular properties is still limited. Here, we uncovered a parvocellular-specific molecule in the dorsal lateral geniculate nucleus (dLGN) of higher mammals. We found that
Otavio S C Mariani et al.
The Journal of comparative neurology, 527(3), 694-717 (2018-03-27)
We propose a partitioning of the primate intraparietal sulcus (IPS) using immunoarchitectural and connectivity criteria. We studied the immunoarchitecture of the IPS areas in the capuchin monkey using Cat-301 and SMI-32 immunohistochemistry. In addition, we investigated the IPS projections to
Vasily Vorobyov et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(1), 234-243 (2013-01-04)
Monocular deprivation (MD) during a critical period of postnatal development produces significant changes in the anatomy and physiology of the visual cortex, and the deprived eye becomes amblyopic. Extracellular matrix molecules have a major role in restricting plasticity such that
Daniel L Felch et al.
Frontiers in neuroanatomy, 6, 12-12 (2012-04-20)
Previous research has suggested that the three physiologically defined relay cell-types in mammalian lateral geniculate nucleus (LGN)-called parvocellular (P), magnocellular (M), and koniocellular (K) cells in primates and X, Y, and W cells in other mammals-each express a unique combination
Anja K E Horn et al.
Frontiers in neuroanatomy, 12, 45-45 (2018-07-05)
The abducens nucleus (nVI) contains several functional cell groups: motoneurons of the singly-innervated twitch muscle fibers (SIF) and those of the multiply-innervated muscle fibers (MIF) of the lateral rectus muscle (LR), internuclear neurons (INTs) projecting to the contralateral oculomotor nucleus
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| MAB5284 | 04053252666223 |
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