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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
CH3CONHC6H4OH
CAS 번호:
Molecular Weight:
151.16
UNSPSC Code:
12352111
NACRES:
NA.25
PubChem Substance ID:
EC Number:
203-157-5
Beilstein/REAXYS Number:
2208089
MDL number:
Assay:
≥99.0%
Form:
powder
InChI key
RZVAJINKPMORJF-UHFFFAOYSA-N
InChI
1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
SMILES string
CC(=O)Nc1ccc(O)cc1
product line
BioXtra
assay
≥99.0%
form
powder
impurities
≤0.0005% Phosphorus (P), ≤0.1% Insoluble matter
ign. residue
≤0.1%
Quality Level
Gene Information
human ... FAAH(2166), PTGS1(5742), PTGS2(5743), TRPV1(7442)
mp
168-172 °C (lit.)
solubility
ethanol: 0.5 M, clear, colorless
anion traces
chloride (Cl-): ≤0.05%, sulfate (SO42-): ≤0.05%
cation traces
Al: ≤0.0005%, Ca: ≤0.0005%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Mg: ≤0.0005%, NH4+: ≤0.05%, Na: ≤0.005%, Pb: ≤0.001%, Zn: ≤0.0005%
유사한 제품을 찾으십니까? 방문 제품 비교 안내
General description
Acetaminophen or paracetamol is an analgesic and antipyretic. It is however a weak non opioid analgesic.
Application
Acetaminophen has been used:
- as an anti-inflammatory drug to test its effect in lipid peroxidation in marine mussels
- to test its effect on neurite outgrowth in gamma-aminobutyric acid-ergic and glutamatergic neurons
- as a hepatocellular injury inducing agent in mice
Analgesic.
Biochem/physiol Actions
Acetaminophen or paracetamol is an inhibitor of prostaglandin synthesis. It is complexed with arachidonic acid in central nervous system resulting in the formation of N-arachidonoylphentolamine, which is essential for the activation of cannabinoid receptor. Acetaminophen is metabolized to toxic N-acetyl-p-benzoquinone imine. Paracetamol is prescribed for osteoarthritis pain and inhibits cyclooxygenase 1 and 2 activities. It is metabolized by the cytochrome P450 enzymes in liver and is implicated in liver toxicity.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
저장 등급
11 - Combustible Solids
wgk
WGK 1
flash_point_f
364.3 °F - Pensky-Martens closed cup
flash_point_c
184.6 °C - Pensky-Martens closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
Effects on feeding rate and biomarker responses of marine mussels experimentally exposed to propranolol and acetaminophen
Sole M, et al.
Analytical and Bioanalytical Chemistry, 396(2), 649-656 (2010)
Paracetamol: mechanisms and updates
Sharma CV and Mehta V
Continuing education in anaesthesia, critical care & pain, 14(4), 153-158 (2013)
Early detection of acute druginduced liver injury in mice by non-invasive NIR fluorescence imaging
Vasquez KO and Peterson JD
Journal of Pharmacology and Experimental Therapeutics, 1(4), 23-23 (2017)
Interactions between Acetaminophen and Phytotherapies: Overview for the Rational Use of Phytotherapics
Ribeiro J, et al.
Journal of Natural Product and Plant Resources, 8(3), 1-14 (2018)
Comparative Sensitivity of Human-Induced Pluripotent Stem Cell-Derived Neuronal Subtypes to Chemically Induced Neurodegeneration
Cohen JD and Tanaka Y
Applied In Vitro Toxicology, 4(4), 347-364 (2018)
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