B1793
Bafilomycin A1
from Streptomyces griseus, ≥90% (HPLC), film, V-ATPase inhibitor
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C35H58O9
CAS 번호:
Molecular Weight:
622.83
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Beilstein/REAXYS Number:
4730700
MDL number:
Assay:
≥90% (HPLC)
Form:
film
제품 이름
Bafilomycin A1 from Streptomyces griseus, ≥90% (HPLC)
Quality Segment
assay
≥90% (HPLC)
form
film
antibiotic activity spectrum
fungi
mode of action
DNA synthesis | interferes, enzyme | inhibits
storage temp.
−20°C
SMILES string
CO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(C)\C=C(OC)C(=O)OC1[C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)[C@H](O2)C(C)C
InChI
1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1
InChI key
XDHNQDDQEHDUTM-JQWOJBOSSA-N
General description
Chemical structure: macrolide
Application
Bafilomycin A1 has been used:
- as an autophagy inhibitor to study its effects on hepatic steatosis in human hepatocytes
- as a vacuolar-type H+ -ATPase inhibitor to study its effects on the cell viability, percentage of PI-positive cells, and glucose-stimulated insulin secretion (GSIS) in mice INS-1 cells
- as a vacuolar-type H+ -ATPase inhibitor to study its effects on tau degradation in human SH-SY5Y cells
Biochem/physiol Actions
A specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.
Bafilomycin A1 inhibits autophagosome-lysosome fusion and autolysosome acidification, the steps involved in the autophagic process that is required for maintaining functional autophagic flux and cellular homeostasis.
Specific inhibitor of vacuolar type H+-ATPase (V-ATPase).
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