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B7273

Bezafibrate

Name: Bezafibrate
Brand: SIGMA

≥98%, peroxisome proliferator-activated receptor agonist, solid

동의어(들):

2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₉H₂₀ClNO₄

CAS 번호:

41859-67-0

Molecular Weight:

361.82

NACRES:

NA.77

PubChem Substance ID:

24891983

UNSPSC Code:

12352200

EC Number:

255-567-9

MDL number:

MFCD00078970

Assay:

≥98%

Form:

solid

Quality level:

200

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속성

제품 이름

Bezafibrate, ≥98%, solid

Quality Level

200

assay

≥98%

form

solid

solubility

DMF: soluble, deionized water: insoluble, methanol: soluble

originator

Roche

SMILES string

CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(O)=O

InChI

1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24)

InChI key

IIBYAHWJQTYFKB-UHFFFAOYSA-N

Gene Information

human ... HBA2(3040), PPARA(5465), PPARD(5467), PPARG(5468)
mouse ... Ppara(19013), Ppard(19015), Pparg(19016)

설명

Application

Bezafibrate has been used:

a supplement in the standard diet (SD) for mice to study its effect on diabetes
to evaluate its effect on hepatitis C virus (HCV) assembly and secretion
to evaluate its effect on gonadal steroidogenesis and spermatogenesis of zebrafish and also used as standard for HPLC

Biochem/physiol Actions

Bezafibrate has the ability to repress HCV assembly and secretion. It is used to treat dyslipidemia.

Bezafibrate is a peroxisome proliferator-activated receptor agonist for PPARα, PPARδ, and PPARγ. Lipoprotein lipase (LPL) activator.

The peroxisome proliferator-activated receptor (PPAR) is a member of the steroid nuclear receptor superfamily. Bezafibrate is a peroxisome proliferator-activated receptor agonist for PPARα, PPARδ, and PPARγ. Lipoprotein lipase (LPL) activator.
PPARgamma agonists, including Bezafibrate, have beneficial effects in the suppression of the inflammatory response during RSV infection and therefore might have clinical efficacy in the course of severe RSV-infection.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

저장 등급

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.