B7273
Bezafibrate
≥98%, peroxisome proliferator-activated receptor agonist, solid
동의어(들):
2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C19H20ClNO4
CAS 번호:
Molecular Weight:
361.82
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
255-567-9
MDL number:
Assay:
≥98%
Form:
solid
제품 이름
Bezafibrate, ≥98%, solid
Quality Segment
assay
≥98%
form
solid
solubility
DMF: soluble, deionized water: insoluble, methanol: soluble
originator
Roche
SMILES string
CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(O)=O
InChI
1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24)
InChI key
IIBYAHWJQTYFKB-UHFFFAOYSA-N
Gene Information
human ... HBA2(3040), PPARA(5465), PPARD(5467), PPARG(5468)
mouse ... Ppara(19013), Ppard(19015), Pparg(19016)
Application
Bezafibrate has been used:
- a supplement in the standard diet (SD) for mice to study its effect on diabetes
- to evaluate its effect on hepatitis C virus (HCV) assembly and secretion
- to evaluate its effect on gonadal steroidogenesis and spermatogenesis of zebrafish and also used as standard for HPLC
Biochem/physiol Actions
Bezafibrate has the ability to repress HCV assembly and secretion. It is used to treat dyslipidemia.
Bezafibrate is a peroxisome proliferator-activated receptor agonist for PPARα, PPARδ, and PPARγ. Lipoprotein lipase (LPL) activator.
The peroxisome proliferator-activated receptor (PPAR) is a member of the steroid nuclear receptor superfamily. Bezafibrate is a peroxisome proliferator-activated receptor agonist for PPARα, PPARδ, and PPARγ. Lipoprotein lipase (LPL) activator.
PPARgamma agonists, including Bezafibrate, have beneficial effects in the suppression of the inflammatory response during RSV infection and therefore might have clinical efficacy in the course of severe RSV-infection.
PPARgamma agonists, including Bezafibrate, have beneficial effects in the suppression of the inflammatory response during RSV infection and therefore might have clinical efficacy in the course of severe RSV-infection.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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