C9012
Bis(cyclohexanone)oxaldihydrazone
≥95% purity (TLC), powder
동의어(들):
Cuprizon, Cuprizone, Oxalic acid bis(cyclohexylidenehydrazide)
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C14H22N4O2
CAS 번호:
Molecular Weight:
278.35
NACRES:
NA.47
PubChem Substance ID:
UNSPSC Code:
12171500
EC Number:
206-729-2
MDL number:
Beilstein/REAXYS Number:
2388004
제품 이름
Bis(cyclohexanone)oxaldihydrazone, ≥95% (TLC)
InChI key
DSRJIHMZAQEUJV-UHFFFAOYSA-N
InChI
1S/C14H22N4O2/c19-13(17-15-11-7-3-1-4-8-11)14(20)18-16-12-9-5-2-6-10-12/h1-10H2,(H,17,19)(H,18,20)
SMILES string
O=C(N\N=C1\CCCCC1)C(=O)N\N=C2/CCCCC2
assay
≥95% (TLC)
form
powder
technique(s)
titration: suitable
color
white/clear to off-white
Quality Level
mp
210-214 °C (lit.)
solubility
acetic acid: 50 mg/mL, colorless to very faintly brown
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
2-8°C
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Application
- Bis(cyclohexanone)oxaldihydrazone (Cuprizone) has been used in mice to study the effect of NG2 (neural/glial antigen 2) proteoglycan on toxic-induced demyelination.
- It has been used to induce demyelination in mice.
- It has been used to study cuprizone-induced demyelination and remyelination in the corpus callosum of mice.
Biochem/physiol Actions
Bis(cyclohexanone)oxaldihydrazone (Cuprizone) is a copper chelator. It results in oligodendroglial cell death, thereby leading to demyelination, astrogliosis and microglia activation. Cuprizone is widely used to study mitochondrial dysfunction-associated primary demyelination and remyelination in the corpus callosum.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Cortical demyelination is prominent in the murine cuprizone model and is strain-dependent.
Skripuletz T, et al.
The American Journal of Pathology, 172, 1053-1061 (2008)
Galanin transgenic mice with elevated circulating galanin levels alleviate demyelination in a cuprizone-induced MS mouse model.
Zhang L, et al.
PLoS ONE, 7, e33901-e33901 (2012)
Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication.
Steelman AJ, et al.
Neuroscience Research, 72, 32-42 (2012)
Tim Clarner et al.
Glia, 60(10), 1468-1480 (2012-06-13)
In multiple sclerosis (MS), gray matter pathology is characterized by less pronounced inflammation when compared with white matter lesions. Although regional differences in the cytoarchitecture may account for these differences, the amount of myelin debris in the cortex during a
Rashad Hussain et al.
Brain : a journal of neurology, 136(Pt 1), 132-146 (2013-02-01)
Myelin regeneration is a major therapeutic goal in demyelinating diseases, and the failure to remyelinate rapidly has profound consequences for the health of axons and for brain function. However, there is no efficient treatment for stimulating myelin repair, and current
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