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E2758

β-Estradiol

Name: β-Estradiol
Brand: SIGMA

BioReagent, powder, suitable for cell culture

동의어(들):

1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₈H₂₄O₂

CAS 번호:

50-28-2

Molecular Weight:

272.38

UNSPSC Code:

12352209

NACRES:

NA.77

PubChem Substance ID:

24894483

EC Number:

200-023-8

Beilstein/REAXYS Number:

1914275

MDL number:

MFCD00003693

Biological source:

synthetic (organic)

Form:

powder

Assay:

≥98% (HPLC)

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도움 문의

속성

biological source

synthetic (organic)

Quality Segment

200

product line

BioReagent

assay

≥98% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable, single cell analysis: suitable

mp

176-180 °C (lit.)

solubility

ethanol: 50 mg/mL, clear, colorless

shipped in

ambient

storage temp.

room temp

SMILES string

O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C

InChI

1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

InChI key

VOXZDWNPVJITMN-ZBRFXRBCSA-N

Gene Information

human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), GPER(2852), SERPINA6(866)
mouse ... Esr1(13982), Esr2(13983), Esrra(26379)
rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)

설명

General description

Listen to an Audio Overview

β-Estradiol or estradiol-17 β (E2) is secreted majorly by the large preovulatory follicles in the ovary. In addition, estradiol can be synthesized de novo from cholesterol have androgens synthesized from cholesterol. The aromatization of androgen by enzyme aromatase (P450arom) results in the β-estradiol production.

Application

β-Estradiol is used to study cell differentiation and transformations (tumorigenicity).

β-Estradiol has been used:

as a component of Dulbecco′s modified Eagle medium (DMEM) for culturing mammary tumor cells
as a oestrogenic compound for testing neuroprotective effects
as a component of medium199 for culturing oocytes

Biochem/physiol Actions

The major estrogen secreted by the premenopausal ovary.

The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

β-Estradiol (E2) is a major premenopausal hormone in women and is essential for spermiogenesis, sperm maturation and motility in men. Cultured bone marrow stem cells (BMSCs) have ability to synthesize E2 and could be exploited for treating estrogen deficiency. It mediates physiological functions through estrogen receptor (ER) α and ERβ.

Physical form

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Preparation Note

To prepare a 20 μg/ml stock solution, add 1 ml absolute ethanol to 1 mg β-estradiol; gently swirl to dissolve; add 49 ml sterile medium while mixing.

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픽토그램

GHS08,GHS09

경고어

Danger

위험 코드

H351,H360Fd,H362,H410,EUH380,EUH430

주의 사항

P201 - P202 - P260 - P263 - P273 - P280 - P308 + P313 - P391 - P405 - P501

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

인화점 (F)

Not applicable

인화점 (°C)