F9765
Filipin complex
powder, ≥70% (UV)
동의어(들):
Filimarisin
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
제품 이름
Filipin complex from Streptomyces filipinensis, ≥70% (UV)
biological source
Streptomyces sp. (Streptomyces filipinensis)
Quality Segment
assay
≥70% (UV)
form
powder
solubility
methanol: 9.80-10.20 mg/mL, clear to hazy, yellow to very deep greenish-yellow
antibiotic activity spectrum
fungi
mode of action
cell membrane | interferes
storage temp.
−20°C
InChI
1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1
InChI key
IMQSIXYSKPIGPD-YQRUMEKGSA-N
General description
Chemical structure: macrolide
Application
Filipin complex from Streptomyces filipinensis has been used as a profluorescence probe to detect the free cholesterol in cell.
Biochem/physiol Actions
Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability and associated functions via binding to membrane sterols. Filipin binds to membrane sterols such as cholesterol, and it both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.
Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability. Filipin binds to model crystalline phase lipid bilayers containing cholesterol, and to liquid phase bilayers with or without cholesterol, in an orientation that forms membrane pores.It both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.
Other Notes
Filipin contains 8 isomeric components, with filipin III as the major component.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable