I7378

Indomethacin

Name: Indomethacin
Brand: SIGMA

98.5-100.5% (in accordance with EP), powder or crystals, COX inhibitor

동의어(들):

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₉H₁₆ClNO₄

CAS 번호:

53-86-1

Molecular Weight:

357.79

NACRES:

NA.77

PubChem Substance ID:

24278173

UNSPSC Code:

12161501

EC Number:

200-186-5

MDL number:

MFCD00057095

Beilstein/REAXYS Number:

497341

Assay:

98.0-102.0% (in accordance with EP)
98.0-102.0%

Form:

powder or crystals

Quality level:

200

주요 문서

모든 문서 보기

기술 서비스

도움이 필요하신가요? 저희 숙련된 과학자 팀이 도와드리겠습니다.

도움 문의

기술 서비스

도움이 필요하신가요? 저희 숙련된 과학자 팀이 도와드리겠습니다.

도움 문의

제품 이름

Indomethacin, 98.0-102.0%, meets EP testing specifications

InChI key

CGIGDMFJXJATDK-UHFFFAOYSA-N

InChI

1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

SMILES string

COc1ccc2n(c(C)c(CC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3

biological source

synthetic

Quality Level

200

Gene Information

human ... ALB(213), ALOX5(240), ELA2(1991), GPR44(11251), IL1A(3552), PLA2G1B(5319), PTGDR(5729), PTGS1(5742), PTGS2(5743)
mouse ... Alox5(11689), Ptgdr(19214), Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219), Ptgs1(19224)
rat ... Alox5(25290), Ptgs1(24693), Ptgs2(29527)

agency

meets EP testing specifications

form

powder or crystals

loss

≤0.5% loss on drying

mp

158-162 °C

mode of action

enzyme | inhibits

assay

98.0-102.0% (in accordance with EP)
98.0-102.0%

유사한 제품을 찾으십니까? 방문 제품 비교 안내

Application

Indomethacin has been used:

as a medium supplement in osteogenic and adipogenic differentiation assays in human bone marrow stem cells
as a medium supplement in bovine amniotic fluid stem cells (BAFSCs) culture
in the inhibition of prostaglandin E2 (PGE2) in T cells

Biochem/physiol Actions

Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Indomethacin is an inhibitor of the enzyme cyclooxygenase 1 and 2. Indomethacin elicits side effects in gastrointestinal tract, kidney and cerebrum. Indomethacin, along with ibuprofen, is effective for treating patent ductus arteriosus (PDA) in infants with respiratory distress syndrome. Rectal indomethacin is effective in treating endoscopic retrograde cholangiography (ERCP) induced pancreatitis.

pictograms

GHS06

signalword

Danger

hcodes

H300

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 1 Oral

저장 등급

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Therapeutic potential of amniotic fluid stem cells to treat bilateral ovarian dystrophy in dairy cows in a subtropical region

Chang LB, et al.

Reproduction in domestic animals = Zuchthygiene, 53(2), 433-441 (2018)

Effectiveness of the use of Rectal Indometacin in the prevention of post-CPRE pancreatitis in the Naval Medical Center.

Islava EE, et al.

INTERNATIONAL JOURNAL OF ADVANCED MULTIDISCIPLINARY RESEARCH, 5(11), 44-51 (2018)

A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus

Van Overmeire B, et al.

The New England Journal of Medicine, 343(10), 674-681 (2000)

Modulation of miRNAs by Vitamin C in Human Bone Marrow Stromal Cells

Kolhe R, et al.

Nutrients, 10(2), 186-186 (2018)

Suppression of T cells by mesenchymal and cardiac progenitor cells is partly mediated via extracellular vesicles

van den Akker F, et al.

Heliyon, 4(6), e00642-e00642 (2018)

모든 관련된 서류 보기

문서

Protein-based Drug Transport

Protein-based drug transporters are expressed in Sf9 cells. Understanding the specific mechanisms of tumor cell transporters is an essential aspect of chemotherapeutic drug design.

Discover Bioactive Small Molecules for ADME/Tox

프로토콜

Guide: Expansion & Differentiation of Human Mesenchymal

TrueGel3D^® Hydrogel Plate protocol guides high-throughput culture of human adipose MSCs for screening applications.

Indomethacin

98.5-100.5% (in accordance with EP), powder or crystals, COX inhibitor

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

InChI key

InChI

SMILES string

biological source

Quality Level

Gene Information

agency

form

loss

mp

mode of action

assay

관련 카테고리

설명

Application

Biochem/physiol Actions

Features and Benefits

General description

안전성 정보

pictograms

signalword

hcodes

pcodes

Hazard Classifications

저장 등급

wgk

flash_point_f

flash_point_c

ppe

문서

시험 성적서(COA)

이 제품을 이미 가지고 계십니까?

관련 참고 논문

관련 참고 프로토콜

문서

프로토콜

관련 콘텐츠

기술 서비스