S7067
SB 202190
≥98% (HPLC), powder, p38 MAP kinase inhibitor
동의어(들):
4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C20H14FN3O
CAS 번호:
Molecular Weight:
331.34
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
제품 이름
SB 202190, ≥98% (HPLC)
SMILES string
Oc1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4
InChI key
QHKYPYXTTXKZST-UHFFFAOYSA-N
InChI
1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
assay
≥98% (HPLC)
form
powder
color
faintly yellow, to beige
solubility
DMSO: 10 mg/mL, clear
originator
GlaxoSmithKline
storage temp.
2-8°C
Quality Level
Gene Information
human ... MAPK14(1432)
Application
SB 202190 has been used:
- to investigate the role of p38mitogen-activated protein kinase (MAPK) signaling in establishment of reovirus infection
- as a p38α inhibitor in in vivo studies to study its impact on the development or progression of adenocarcinoma in the colon mucosa tissues of APC Min/+ mice.
- as a component of basic BC medium to culture basal progenitor cells.
- as a component of normal endometrium and endometrial tumor media for organoid culture.
SB 202190 was used to inhibit p38 activation in MCF7 cells5, mouse macrophages6 and HepG2 cells.7
Biochem/physiol Actions
SB 202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinase. SB 202190 binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms.
Features and Benefits
This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
General description
SB202190 aids in enhancing the self-renewal ability of neural stem cells fromNPC1-deficient mice.
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
저장 등급
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
NPC1 gene deficiency leads to lack of neural stem cell self-renewal and abnormal differentiation through activation of p38 mitogen-activated protein kinase signaling
Yang SR, et al.
Journal of Separation Science, 24(2), 292-298 (2006)
Uncoupling p38? nuclear and cytoplasmic functions and identification of two p38? phosphorylation sites on ?-catenin: implications for the Wnt signaling pathway in CRC models
Lepore Signorile M, et al.
Journal of Separation Science, 13(1), 223-223 (2023)
Protocol for generating airway organoids from 2D air liquid interface-differentiated nasal epithelia for use in a functional CFTR assay
Rodenburg LW, et al.
STAR protocols, 4(3), 102337-102337 (2023)
p38 Mitogen-Activated Protein Kinase Signaling Enhances Reovirus Replication by Facilitating Efficient Virus Entry, Capsid Uncoating, and Postuncoating Steps
Mohamed A, et al.
American journal of virology, 97(2), e0000923-e0000923 (2023)
Edward Thorp et al.
The Journal of biological chemistry, 286(38), 33335-33344 (2011-08-11)
Mer tyrosine kinase (MerTK) is an integral membrane protein that is preferentially expressed by phagocytic cells, where it promotes efferocytosis and inhibits inflammatory signaling. Proteolytic cleavage of MerTK at an unidentified site leads to shedding of its soluble ectodomain (soluble
관련 콘텐츠
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.