SML0737
MitoTEMPO
≥98% (HPLC), powder, antioxidant
동의어(들):
(2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride, Mito-TEMPO
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C29H35N2O2P · Cl
CAS 번호:
Molecular Weight:
510.03
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
Storage condition:
desiccated, protect from light
제품 이름
MitoTEMPO, ≥98% (HPLC)
SMILES string
[P+](CC(=O)NC4CC(N(C(C4)(C)C)[O])(C)C)(c3ccccc3)(c2ccccc2)c1ccccc1.[Cl-]
InChI
1S/C29H34N2O2P.ClH/c1-28(2)20-23(21-29(3,4)31(28)33)30-27(32)22-34(24-14-8-5-9-15-24,25-16-10-6-11-17-25)26-18-12-7-13-19-26;/h5-19,23H,20-22H2,1-4H3;1H
InChI key
WKKFJIJNGHNQQW-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated, protect from light
color
white to light brown
solubility
H2O: 10 mg/mL, clear
storage temp.
−20°C
Quality Level
관련 카테고리
Application
MitoTEMPO has been used as a mitochondria-targeted antioxidant.
Biochem/physiol Actions
MitoTEMPO is a mitochondrially targeted antioxidant, a specific scavenger of mitochondrial superoxide.
MitoTEMPO is a mitochondrially targeted antioxidant, a specific scavenger of mitochondrial superoxide. MitoTEMPO is a combination of the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, giving MitoTEMPO the ability to pass through lipid bilayers with ease and accumulate several hundred-fold in mitochondria. Mitochondrial dysfunction and oxidative stress contribute to a variety of disorders involving cardiovascular, kidney, liver disorders, Parkinson′s and Alzheimer′s disease.
Other Notes
Light sensitive
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Eunice E To et al.
Antioxidants & redox signaling, 32(13), 929-942 (2019-06-14)
Aims: Reactive oxygen species (ROS) are highly reactive molecules generated in different subcellular sites or compartments, including endosomes via
Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy
Yu C, et al.
The Journal of Biological Chemistry (2016)
Modulation of mitochondrial antiviral signaling by human herpesvirus 8 interferon regulatory factor 1
Young KH, et al.
Journal of Virology (2016)
Zimei Wu et al.
Zebrafish, 16(2), 171-181 (2019-02-07)
Chemical interventions are regularly used to examine and manipulate macrophage function in larval zebrafish. Given chemicals are typically administered by simple immersion or injection, it is not possible to resolve whether their impact on macrophage function is direct or indirect.
Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration
Xiaoying L, et al.
Redox Biology, 508-521 (2017)
문서
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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