SML0737
MitoTEMPO
≥98% (HPLC), powder, antioxidant
동의어(들):
(2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride, Mito-TEMPO
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C29H35N2O2P · Cl
CAS 번호:
Molecular Weight:
510.03
UNSPSC Code:
12352200
NACRES:
NA.77
제품 이름
MitoTEMPO, ≥98% (HPLC)
SMILES string
[P+](CC(=O)NC4CC(N(C(C4)(C)C)[O])(C)C)(c3ccccc3)(c2ccccc2)c1ccccc1.[Cl-]
InChI
1S/C29H34N2O2P.ClH/c1-28(2)20-23(21-29(3,4)31(28)33)30-27(32)22-34(24-14-8-5-9-15-24,25-16-10-6-11-17-25)26-18-12-7-13-19-26;/h5-19,23H,20-22H2,1-4H3;1H
InChI key
WKKFJIJNGHNQQW-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated, protect from light
color
white to light brown
solubility
H2O: 10 mg/mL, clear
storage temp.
−20°C
Quality Level
관련 카테고리
Application
MitoTEMPO has been used as a mitochondria-targeted antioxidant.
Biochem/physiol Actions
MitoTEMPO is a mitochondrially targeted antioxidant, a specific scavenger of mitochondrial superoxide.
MitoTEMPO is a mitochondrially targeted antioxidant, a specific scavenger of mitochondrial superoxide. MitoTEMPO is a combination of the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, giving MitoTEMPO the ability to pass through lipid bilayers with ease and accumulate several hundred-fold in mitochondria. Mitochondrial dysfunction and oxidative stress contribute to a variety of disorders involving cardiovascular, kidney, liver disorders, Parkinson′s and Alzheimer′s disease.
Other Notes
Light sensitive
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Eunice E To et al.
Antioxidants & redox signaling, 32(13), 929-942 (2019-06-14)
Aims: Reactive oxygen species (ROS) are highly reactive molecules generated in different subcellular sites or compartments, including endosomes via
Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy
Yu C, et al.
The Journal of Biological Chemistry (2016)
Modulation of mitochondrial antiviral signaling by human herpesvirus 8 interferon regulatory factor 1
Young KH, et al.
Journal of Virology (2016)
Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration
Xiaoying L, et al.
Redox Biology, 508-521 (2017)
Qianming Du et al.
Biochemical pharmacology, 105, 42-54 (2016-02-28)
Prolonged ingestion of a cholesterol-enriched diet induces chronic, auto-inflammatory responses resulting in significant health problems including colorectal cancer. Inflammasomes are thought to mediate intestinal homeostasis, and their dysregulation contributes to inflammatory bowel diseases and colitis-associated cancer (CAC). However, in vitro
문서
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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