T1147
apo-Transferrin human
powder, BioReagent, suitable for cell culture, ≥98% (agarose gel electrophoresis)
동의어(들):
Human transferrin, Siderophilin
제품 이름
apo-Transferrin human, powder, BioReagent, suitable for cell culture, ≥98% (agarose gel electrophoresis)
biological source
human plasma
product line
BioReagent
assay
≥98% (agarose gel electrophoresis)
form
powder
mol wt
76-81 kDa
concentration
~25 mM
technique(s)
cell culture | mammalian: suitable
impurities
HIV and HBsAg, source material tested negative
≤0.005% iron
solubility
H2O: 50 mg/mL
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Quality Level
Gene Information
human ... TF(7018)
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Application
Apo-Transferrin human can be supplemented with iron or used to bind free iron present in media. It is also used to transport iron into mammalian cells.
Biochem/physiol Actions
Transferrin is the primary iron binding and cell delivery molecule present in serum. Serum-free cell culture systems require a delivery format for iron. Transferrin is the preferential delivery form of iron because cells process transferrin bound iron in a physiologically appropriate way through transferrin receptors on the cell surface. Human apo-transferrin is a high affinity transferrin that can be used with a wide range of cells types. Apo-transferrin can be loaded with iron prior to use or added directly to an iron containing medium.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Other Notes
Non-heme iron-transport protein.
저장 등급
11 - Combustible Solids
wgk
WGK 3
Giang D Nguyen et al.
PloS one, 8(8), e72698-e72698 (2013-08-24)
Huntington's disease (HD) is a neurodegenerative disease caused by abnormal polyglutamine expansion in the huntingtin protein (Htt). Although both Htt and the HD pathogenic mutation (mHtt) are implicated in early developmental events, their individual involvement has not been adequately explored.
Giang D Nguyen et al.
PloS one, 9(5), e96858-e96858 (2014-05-08)
H1 linker histone proteins are essential for the structural and functional integrity of chromatin and for the fidelity of additional epigenetic modifications. Deletion of H1c, H1d and H1e in mice leads to embryonic lethality by mid-gestation with a broad spectrum
Kathleen N O'Guin et al.
ASN neuro, 6(1), e00135-e00135 (2014-01-31)
The molecular requirements for human myelination are incompletely defined, and further study is needed to fully understand the cellular mechanisms involved during development and in demyelinating diseases. We have established a human co-culture model to study myelination. Our earlier observations
Peripheral nervous system genes expressed in central neurons induce growth on inhibitory substrates.
William J Buchser et al.
PloS one, 7(6), e38101-e38101 (2012-06-16)
Trauma to the spinal cord and brain can result in irreparable loss of function. This failure of recovery is in part due to inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans (CSPGs). Peripheral nervous system (PNS) neurons exhibit
Ayumu Suzuki et al.
Nature communications, 7, 11056-11056 (2016-03-31)
Meiosis is a unique process that allows the generation of reproductive cells. It remains largely unknown how meiosis is initiated in germ cells and why non-germline cells do not undergo meiosis. We previously demonstrated that knockdown of Max expression, a
문서
Understand how transferrin affects serum-free cell culture systems, crucial for biomanufacturing heterologous proteins like monoclonal antibodies.
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Instructions
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