136824
3,3-Dimethyl-2-butanol
98%
Synonym(s):
tert-Butyl methyl carbinol, Pinacoline alcohol, Pinacolyl alcohol
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About This Item
Linear Formula:
(CH3)3CCH(OH)CH3
CAS Number:
Molecular Weight:
102.17
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
207-347-9
Beilstein/REAXYS Number:
1718948
MDL number:
Assay:
98%
Form:
liquid
InChI key
DFOXKPDFWGNLJU-UHFFFAOYSA-N
InChI
1S/C6H14O/c1-5(7)6(2,3)4/h5,7H,1-4H3
SMILES string
CC(O)C(C)(C)C
assay
98%
form
liquid
refractive index
n20/D 1.415 (lit.)
bp
119-121 °C (lit.)
mp
4.8 °C (lit.)
density
0.812 g/mL at 25 °C (lit.)
functional group
hydroxyl
Quality Level
Related Categories
General description
3,3-Dimethyl-2-butanol is a potential precursor for prohibited chemical weapons such as soman, a nerve agent. It is a synthetic analog of kairomone.
Application
3,3-Dimethyl-2-butanol was used in conversion of ribose- and glucose-binding proteins into receptors for pinacolyl methyl phosphonic acid.
3,3-Dimethyl-2-butanol (pinacolyl alcohol) can be used as a substrate:
- To study the oxidation of secondary alcohols to ketones using cyclic microwave heating technique.
- To prepare aryl ethers by reacting with aryl iodide using 4-pyrrolidinopyridine ligand via Cu-catalyzed Ullmann reaction.
signalword
Warning
hcodes
Hazard Classifications
Flam. Liq. 3
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
78.8 °F - closed cup
flash_point_c
26 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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J T James et al.
Journal of applied toxicology : JAT, 7(5), 307-312 (1987-10-01)
Sprague-Dawley rats were given 15, 70 and 140 min exposures to 15 mg/l 3,3-dimethyl-2-butanol, pinacolyl alcohol (PA), or 6-hour exposures to 0.2, 1.0 and 5.0 mg/l PA (1 mg/l = 240 ppm). A 50% mortality rate was obtained at the
3, 3-Dimethyl-1-butanol, a parakairomone component to Aleurodicus dispersus (Hemiptera: Aleyrodidae).
Zheng L-X, et al.
Arthropod-Plant Interactions, 7, 1-7 (2013)
J T James et al.
Journal of applied toxicology : JAT, 7(2), 135-142 (1987-04-01)
Four groups of male and female Sprague-Dawley rats were exposed for 13 weeks to 3,3-dimethyl-2-butanol (PA) at concentrations of 0.00, 0.20, 1.00 or 5.00 mg/l (1 mg/l = 240 ppm). Exposures were for 6 hr per day, 5 days per
Ullmann CO coupling of sterically hindered secondary alcohols using excess amount of strongly coordinating monodentate ligands
Sugata H, et al.
Tetrahedron Letters, 58(10), 1015-1019 (2017)
W E Luttrell et al.
Biochemical pharmacology, 46(11), 2083-2092 (1993-12-03)
Soman (pinacolyl methylphosphonofluoridate), a highly toxic organophosphate compound, has been found to be a strong inhibitor of hepatic microsomal carboxylesterase in vitro, but an enhancer of carboxylesterase when administered in vivo. In response to this paradoxical observation, the objective of
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