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Merck

1.06176

Methanol

greener alternative

BioRenewable, ≥99.9% (GC), suitable for LC-MS, LiChrosolv®

Synonym(s):

Methyl alcohol

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About This Item

Linear Formula:
CH3OH
CAS Number:
67-56-1
Molecular Weight:
32.04
UNSPSC Code:
12191502
NACRES:
NA.03
EC Index Number:
200-659-6
MDL number:
MFCD00004595
Beilstein/REAXYS Number:
1098229
Assay:
≥99.9% (GC)
Bp:
64.7 °C (lit.)
Vapor pressure:
128 hPa ( 20 °C), 410 mmHg ( 50 °C), 97.68 mmHg ( 20 °C)

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vapor density

1.11 (vs air)

Quality Level

100

vapor pressure

128 hPa ( 20 °C), 410 mmHg ( 50 °C), 97.68 mmHg ( 20 °C)

product line

LiChrosolv®

assay

≥99.9% (GC)

autoignition temp.

725 °F

expl. lim.

36 %

greener alternative product characteristics

Safer Solvents and Auxiliaries
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

impurities

≤0.0002 meq/g Acidity, ≤0.0002 meq/g Alkalinity, ≤0.01% Water, ≤10 ppb Aluminium (Al), ≤10 ppb Calcium (Ca), ≤10 ppb Iron (Fe), ≤10 ppb Magnesium (Mg), ≤10 ppb Sodium (Na), ≤5 ppb Any further metal (ICP-MS), ≤5 ppb Potassium (K)

transmittance

210 nm, ≥35%, 220 nm, ≥60%, 230 nm, ≥75%, 260 nm, ≥98%

refractive index

n20/D 1.329 (lit.), n/D (n20/D 1.329)(lit.)

kinematic viscosity

0.54-0.59 cSt(20 °C)

bp

64.7 °C (lit.)

mp

−98 °C (lit.)

transition temp

flash point 9.7 °C

density

0.791 g/mL at 25 °C (lit.)

UV absorption

λ: 225 nm Amax: ≤0.170

suitability

suitable for HPLC, suitable for LC-MS

SMILES string

CO

format

neat

greener alternative category

Aligned

InChI

1S/CH4O/c1-2/h2H,1H3

InChI key

OKKJLVBELUTLKV-UHFFFAOYSA-N

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General description

LiChrosolv® solvents are specially formulated to meet the demanding needs of analytical HPLC applications. With exceptional UV transmittance, minimal particle count, and controlled acidity and alkalinity, our solvents ensure reproducible separations every time. The low evaporation residue level further enhances their performance, making them the ideal choice for high-quality results. The product line includes both "gradient grade" and "isocratic grade" solvents, specifically designed to reduce the gradient effect during separations. This tailored approach allows for optimal consistency and accuracy in your analytical processes, helping you achieve the best possible outcomes in your chromatography work.
This bio-based solvent for LC-MS offers the same precisionand reliability you trust, now with more sustainability.

  • Derived from renewable feedstocks with bio-carbon content certification
  • Similar chromatographic resolution, reproducibility, and baseline stability
  • Drop-in replacement: no method redevelopment required
We are committed to bringing you greener alternative products that adhere to one or more of the 12 Principles of Greener Chemistry, and this bio-based (BioRenewable) product aligns with the principles of Safer Solvents and Auxiliaries and Use of Renewable Feedstocks.

Application

  • Reversed-Phase HPLC: Commonly used as a mobile phase component for the separation of a wide range of compounds, including pharmaceuticals, environmental pollutants, and biomolecules.
  • Gradient Elution: Ideal for gradient elution techniques, enhancing the resolution and separation efficiency of complex mixtures.
  • Pharmaceutical Analysis: Frequently employed in the analysis of active pharmaceutical ingredients (APIs) and their impurities, ensuring compliance with regulatory standards.
  • Biological Sample Analysis: Used for the analysis of proteins, peptides, and metabolites in biological samples, facilitating accurate quantification and identification.
  • Environmental Monitoring: Applied in the HPLC analysis of environmental samples to detect and quantify contaminants in water, soil, and air.

Features and Benefits

  • High Purity: Formulated with minimal impurities, ensuring reliable and reproducible results essential for sensitive analytical applications.
  • Excellent UV Transparency: Provides optimal UV transmittance, facilitating accurate detection and enhancing sensitivity in HPLC analyses.
  • Low Evaporation Residue: Minimizes contamination risk, leading to cleaner separations and improved analytical reliability.
  • Batch-to-Batch Consistency: Ensures uniform quality and performance across different production batches, enhancing reproducibility, and confidence in analytical results.

Analysis Note

  • Evaporation Number: 1.9
  • Purity (GC): ≥ 99.9 %
  • Identity (IR): conforms
  • Evaporation residue: ≤ 1.0 mg/l
  • Gradient grade (at 220 nm): ≤ 2.0 mAU
  • Gradient grade (at 235 nm): ≤ 1.0 mAU
  • Fluorescence (as quinine at 254 nm): ≤ 1.0 ppb
  • Fluorescence (as quinine at 365 nm): ≤ 0.5 ppb
  • Transmission (at 210 nm): ≥ 35 %
  • Transmission (at 220 nm): ≥ 60 %
  • Transmission (at 230 nm): ≥ 75 %
  • Transmission (from 260 nm): ≥ 98 %
  • Suitable for LC-MS; Intensity of background mass peak based on reserpine(APCI/ESI positive): ≤ 2 ppb
  • Suitable for LC-MS; Intensity of background mass peak based on reserpine(APCI/ESI negative): ≤ 20 ppb Filtered by 0.2 µm filter.

Other Notes

Available with Data Matrix Code

This high-quality LCMS-grade solvent now features a unique Data Matrix Code on its label, providing digital access to essential product information such as batchnumber, product number, and expiry date. Unlike standard barcodes, our DMCs feature a unique serial number for each bottle, enabling you to monitor and trace every bottle individually. With standard barcodes, all bottles from the same batch look identical. Our solution gives you true bottle-level traceability for greater control and compliance in the lab.
Bio-Based LC-MS Solvents

LiChrosolv™ bio-based solvents are derived from renewable feedstocks and verified through bio-carbon content certification. They provide comparable chromatographic performance to conventional solvents; same resolution, reproducibility, and baseline stability; and function as drop-in replacements requiring no method redevelopment.

Legal Information

LICHROSOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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