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Merck

1.06188

Methanol

greener alternative

BioRenewable, gradient grade (for liquid chromatography), LiChrosolv®, reag. Ph. Eur.

Synonym(s):

Methyl alcohol

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About This Item

Linear Formula:
CH3OH
CAS Number:
Molecular Weight:
32.04
NACRES:
NA.03
UNSPSC Code:
12191502
Beilstein/REAXYS Number:
1098229
MDL number:
Assay:
≥99.9% (GC)
Bp:
64.7 °C (lit.)
Vapor pressure:
128 hPa ( 20 °C), 410 mmHg ( 50 °C), 97.68 mmHg ( 20 °C)
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agency

reag. Ph. Eur.

Quality Level

vapor density

1.11 (vs air)

vapor pressure

128 hPa ( 20 °C), 410 mmHg ( 50 °C), 97.68 mmHg ( 20 °C)

product line

LiChrosolv®

grade

gradient grade (for liquid chromatography), gradient grade

assay

≥99.9% (GC)

autoignition temp.

725 °F

expl. lim.

36 %

greener alternative product characteristics

Safer Solvents and Auxiliaries
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

impurities

≤0.0002 meq/g Acidity, ≤0.0002 meq/g Alkalinity, ≤0.02% Water

transmittance

210 nm, ≥20%, 220 nm, ≥60%, 230 nm, ≥75%, 235 nm, ≥83%, 250 nm, ≥95%, 260 nm, 98%

refractive index

n20/D 1.329 (lit.), n/D (n20/D 1.329)(lit.)

bp

64.7 °C (lit.)

mp

−98 °C (lit.)

transition temp

flash point 9.7 °C

density

0.791 g/mL at 25 °C (lit.)

absorption

≤0.01 at 260 nm, ≤0.02 at 250 nm, ≤0.07 at 240 nm, ≤0.13 at 230 nm, ≤0.170 at 225 nm, ≤0.30 at 220 nm, ≤0.70 at 210 nm

UV absorption

λ: 225 nm Amax: ≤0.170

SMILES string

CO

suitability

suitable for HPLC

application(s)

(HPLC)

greener alternative category

InChI

1S/CH4O/c1-2/h2H,1H3

InChI key

OKKJLVBELUTLKV-UHFFFAOYSA-N

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General description

LiChrosolv®solvents are specially formulated to meet the demanding needs of analytical HPLC applications. With exceptional UV transmittance, minimal particle count, and controlled acidity and alkalinity, our solvents ensure reproducible separations every time. The low evaporation residue level further enhances their performance, making them the ideal choice for high-quality results. The product line includes both "gradient grade" and "isocratic grade" solvents, specifically designed to reduce the gradient effect during separations. This tailored approach allows for optimal consistency and accuracy in your analytical processes, helping you achieve the best possible outcomes in your chromatography work.
This bio-based solvent for LC offers the same precision and reliability you trust, now with more sustainability.

  • Derived from renewable feedstocks with bio-carbon content certification
  • Similar chromatographic resolution, reproducibility, and baseline stability
  • Drop-in replacement: no method redevelopment required
We are committed to bringing you greener alternative products that adhere to one or more of the 12 Principles of Greener Chemistry, and this bio-based (BioRenewable) product aligns with the principles of Safer Solvents and Auxiliaries and Use of Renewable Feedstocks.

Application

  • Reversed-Phase HPLC: Commonly used as a mobile phase component for the separation of a wide range of compounds, including pharmaceuticals, environmental pollutants, and biomolecules.
  • Gradient Elution: Ideal for gradient elution techniques, enhancing the resolution, and separation efficiency of complex mixtures.
  • Pharmaceutical Analysis: Frequently employed in the analysis of active pharmaceutical ingredients (APIs) and their impurities, ensuring compliance with regulatory standards.
  • Biological Sample Analysis: Used for the analysis of proteins, peptides, and metabolites in biological samples, facilitating accurate quantification and identification.
  • Environmental Monitoring: Applied in the HPLC analysis of environmental samples to detect and quantify contaminants in water, soil, and air.

Features and Benefits

  • High Purity: Formulated with minimal impurities, ensuring reliable and reproducible results essential for sensitive analytical applications.
  • Excellent UV Transparency: Provides optimal UV transmittance, facilitating accurate detection and enhancing sensitivity in HPLC analyses.
  • Low Evaporation Residue: Minimizes contamination risk, leading to cleaner separations and improved analytical reliability.
  • Batch-to-Batch Consistency: Ensures uniform quality and performance across different production batches, enhancing reproducibility, and confidence in analytical results.

Analysis Note

  • Evaporation Number: 1.9
  • Identity (IR): conforms
  • Evaporation residue: ≤ 2.0 mg/l
  • Color: ≤ 10
  • Density (d 20 °C/20 °C): 0.791 - 0.793
  • Gradient grade (at 235 nm): ≤ 2.0 mAU
  • Gradient grade (at 254 nm): ≤ 1.0 mAU
  • Filtered by 0.2 µm filter. Suitable for UPLC / UHPLC /Ultra HPLC - instruments.
  • Conforms to Methanol R1 and R2 according to Reag. Ph Eur; conforms to the requirements of ACS for liquid chromatography suitability.

Other Notes

Available with Data Matrix Code

This high-quality HPLC-grade solvent now features a unique Data Matrix Code on its label, providing digital access to essential product information such as batch number, product number, and expiry date. Unlike standard barcodes, our DMCs feature a unique serial number for each bottle, enabling you to monitor and trace every bottle individually. With standard barcodes, all bottles from the same batch look identical. Our solution gives you true bottle-level traceability for greater control and compliance in the lab. Know more about our data matrix code-labeled HPLC-grade solvents.
Bio-BasedLC-MS Solvents

LiChrosolv® bio-based solvents are derived from renewable feedstocks and verified through bio-carbon content certification. They provide comparable chromatographic performance to conventional solvents—same resolution, reproducibility, and baseline stability—and function as drop-in replacements requiring no method redevelopment

Legal Information

LICHROSOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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