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50246

Poloxamer 407, micronized

Synonym(s):

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lμtrol micro 127

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About This Item

CAS Number:
9003-11-6
UNSPSC Code:
12161900
NACRES:
NA.25
MDL number:
MFCD00082049
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mol wt

~9840-14600 g/mol

Quality Level

100

composition

oxyethylene content, 71.5-74.9%

impurities

≤0.25% ethylene glycol and diethylene glycol, ≤0.4% total ash, ≤0.75% water, ≤1 ppm ethylene oxide, ≤2 ppm arsenic, ≤20 ppm heavy metals, 50-125 ppm butylhydroxytoluene

ign. residue

≤0.30%

color

APHA: ≤120

particle size distribution

, coeff var ≤10% (residue, No. 140 USS), , coeff var ≤50% (residue, No. 270 USS)

pH

5.0-7.5(1:10), 5.0-7.5(1:40)

suitability

complies for Infrared spectrum

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

Application

The Poloxamer 407 grades are poloxamers from the extensive line of Pluronic® block copolymers. They are widely used as a thickening agent and gel binder.

Analysis Note

residual solvents (GLC-HS)
1,4-dioxane ≤5 ppm, ethylene glycol ≤620 ppm ( verified on random samples only)

Other Notes

average molecular weight/mass 9840-14600 g/mol; average molecular mass 10000-14600 g/mol

Legal Information

Pluronic is a registered trademark of BASF

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN7986
BCCL1662
BCCH9437
BCCF0240
BCCB5869

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Irshad A Wani et al.
Colloids and surfaces. B, Biointerfaces, 101, 243-250 (2012-09-27)
Silver nanoparticles have been synthesized in the inverse microemulsions formed using three different surfactants viz., cetyl-trimethyl ammonium bromide (CTAB), Tergitol and Triton X-100. We have done a systematic study of the effect of the surfactants on the particle size and
Wendell J Lu et al.
Lipids, 47(6), 571-580 (2012-02-03)
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretins produced in the intestine that play a central role in glucose metabolism and insulin secretion. Circulating concentrations of GLP-1 and GIP are low and can be difficult to assay in
Yanbin Guan et al.
Archives of pharmacal research, 34(10), 1719-1728 (2011-11-15)
The aim of the present study was to evaluate the effect of pluronic P123 (P123) and pluronic F127 (F127) on intestinal P-glycoprotein (P-gp) and cytochrome P450 3A using the specific substrates rhodamine-123 (R-123) and midazolam, respectively. Caco-2 cells and everted
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